{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:19:47Z","timestamp":1762100387710},"reference-count":90,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":4102,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1994,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We initiated a genome\u2010wide search for genes predisposing to schizophrenia by ascertaining 9 families, each containing three to five cases of schizophrenia. The 9 pedigrees were initially genotyped with 329 polymorphic DNA loci distributed throughout the genome. Assuming either autosomal dominant or recessive inheritance, 254 DNA loci yielded lod scores less than \u22122.0 at \u03b8 = 0.0, 101 DNA markers gave lod scores less than \u22122.0 at \u03b8 = 0.05, while 5 DNA loci produced maximum lod scores greater than 1: D4S35, D14S17, D15S1, D22S84, and D22S55. Of the DNA markers yielding lod scores greater than 1, D4S35 and D22S55 also were suggestive of linkage when the Affected\u2010Pedigree\u2010Member method was used. The families were then genotyped with four highly polymorphic simple sequence repeat markers; possible linkage diminished with DNA markers mapping nearby D4S35, while suggestive evidence of linkage remained with loci in the region of D22S55. Although follow\u2010up investigation of these chromosomal regions may be warranted, our linkage results should be viewed as preliminary observations, as 35 unaffected persons are not past the age of risk. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320540111","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:50:17Z","timestamp":1118512217000},"page":"59-71","source":"Crossref","is-referenced-by-count":137,"title":["Genomic scan for genes predisposing to schizophrenia"],"prefix":"10.1002","volume":"54","author":[{"given":"Hilary","family":"Coon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Holik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Hoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Myles\u2010Worsley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Reimherr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Wender","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merilyne","family":"Waldo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Freedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Leppert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Byerley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Diagnostic and Statistical Manual","author":"American Psychiatric Association","year":"1987"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91660-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.161.3.323"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-03-00924.1992"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90407-6"},{"key":"e_1_2_1_7_1","first-page":"314","article-title":"Construction of a genetic linkage map in man using restriction fragment length polymorphisms","volume":"32","author":"Botstein D","year":"1980","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90058-M"},{"key":"e_1_2_1_9_1","first-page":"1270","article-title":"Localization of the gene coding the primary subunit (NMDARI) of the NMDA receptor channel to chromosome 9q34","volume":"53","author":"Brett PM","year":"1993","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90275-4"},{"key":"e_1_2_1_11_1","first-page":"911","article-title":"A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position\u2010specific recombination rates","volume":"48","author":"Buetow KH","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_12_1","unstructured":"ByerleyW LalouelJ. M. HolikJ StaufferD WenderP WhiteR(1988)Utah molecular genetic study of schizophrenia. New Research Abstract Annual Meeting of the American Psychiatric Association May p50."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90134-3"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041444-199321000-00005"},{"key":"e_1_2_1_15_1","first-page":"328","article-title":"Linkage analysis of schizophrenia with five dopamine receptors in nine pedigrees","volume":"52","author":"Coon H","year":"1993","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_16_1","first-page":"621","article-title":"Genetic mapping of the \u03b21 GABA receptor gene to human chromosome 4, using a tetranucleotide repeat polymorphism","volume":"49","author":"Dean M","year":"1992","journal-title":"Arm J Hum Genet"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/340391a0"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90362-I"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90079-T"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370070104"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770310043002"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700038824"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(91)81406-X"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370010307"},{"key":"e_1_2_1_25_1","volume-title":"Schizophrenia. The Epigenetic Puzzle","author":"Gottesman I","year":"1982"},{"key":"e_1_2_1_26_1","first-page":"828","article-title":"A human D1 dopamine receptor gene is located on chromosome 5 at q35.1 and identifies an EcoRI RFLP","volume":"46","author":"Grandy DK","year":"1990","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(90)90218-J"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90341-9"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90431-D"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132773"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000154115"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(90)90167-S"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(90)90471-6"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.140.11.1413"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/336167a0"},{"key":"e_1_2_1_36_1","first-page":"510","article-title":"Power and sample size in linkage studies. Human Gene Mapping 7. Seventh International Workshop on Human Gene Mapping","volume":"37","author":"Kidd KK","year":"1984","journal-title":"Cytogenet Cell Genet"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.11.3443"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(88)90128-0"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(89)90128-6"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.11.3909"},{"key":"e_1_2_1_41_1","first-page":"425","article-title":"A primary genetic map of chromosome 13q","volume":"39","author":"Leppert M","year":"1986","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-9964(89)90004-2"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810310061011"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3029872"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(88)90133-4"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(88)90125-5"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(88)90161-9"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(89)90317-0"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(89)90139-0"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1439770"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(87)90110-8"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(88)90129-2"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(89)90308-X"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(89)90115-8"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.4.5.2155149"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.11.4175"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370070109"},{"key":"e_1_2_1_58_1","first-page":"219","article-title":"Invited Editorial: Cutting a gordian knot in the linkage analysis of complex human traits","volume":"46","author":"Ott J","year":"1990","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_59_1","volume-title":"Analysis of Human Genetic Linkage","author":"Ott J","year":"1991"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(87)90051-6"},{"key":"e_1_2_1_61_1","first-page":"426","article-title":"Letter to the editor: Programs for determining complex genetic models for linkage analysis: GET\u2010MODEL and GET\u2010PAR","volume":"8","author":"Plaetke R","year":"1992","journal-title":"Genet Epidemiol"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/19.22.6345"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370070103"},{"key":"e_1_2_1_64_1","first-page":"1059","article-title":"A note on multiple testing procedures in linkage analysis","volume":"48","author":"Risch N","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_65_1","first-page":"1039","article-title":"Segregation analysis of schizophrenia and related disorders","volume":"36","author":"Risch N","year":"1984","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_66_1","first-page":"469","article-title":"An hypothesis suggesting that there is a defect in the GABA system in schizophrenia","volume":"10","author":"Roberta E","year":"1972","journal-title":"Neurosci Res Bull"},{"key":"e_1_2_1_67_1","doi-asserted-by":"crossref","first-page":"12753","DOI":"10.1016\/S0021-9258(19)38218-3","article-title":"Molecular scanning methods of mutation detection","volume":"265","author":"Rossiter BJF","year":"1990","journal-title":"J Biol Chem"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/336164a0"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(89)90819-7"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/347146a0"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770300115013"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/339305a0"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1993.01820150055005"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/350614a0"},{"key":"e_1_2_1_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/19.1.105"},{"key":"e_1_2_1_76_1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/350610a0","article-title":"Cloning of the gene for a human dopamine 04 receptor with high affinity for the antipsychotic clozapine","volume":"350","author":"Van Tol HHM","year":"1991","journal-title":"Nature"},{"key":"e_1_2_1_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370090106"},{"key":"e_1_2_1_78_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1993.01820150062006"},{"key":"e_1_2_1_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(89)90282-6"},{"key":"e_1_2_1_80_1","first-page":"388","article-title":"Abundant class of human DNA polymorphisms which can be typing using the polymerase chain reaction","volume":"44","author":"Weber JL","year":"1989","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_81_1","first-page":"315","article-title":"The affected\u2010pedigree\u2010member method of linkage analysis","volume":"42","author":"Weeks DE","year":"1988","journal-title":"Am J Hum Genet"},{"issue":"3","key":"e_1_2_1_82_1","first-page":"A204","article-title":"SLINK: a general method simulation program for linkage analysis","volume":"47","author":"Weeks DE","year":"1990","journal-title":"Am J Hum Genet"},{"issue":"17","key":"e_1_2_1_83_1","first-page":"3.185","article-title":"A genetic linkage map of human chromosome 5 with 60 RFLP loci","volume":"10","author":"Weiffenbach B","year":"1991","journal-title":"Genomics"},{"key":"e_1_2_1_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/359794a0"},{"key":"e_1_2_1_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(90)90469-B"},{"key":"e_1_2_1_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.13.5857"},{"key":"e_1_2_1_87_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.148.6.714"},{"key":"e_1_2_1_88_1","volume-title":"Schizophrenia: An International Follow\u2010up Study","author":"World Health Organization","year":"1979"},{"key":"e_1_2_1_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-9964(88)90034-5"},{"key":"e_1_2_1_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90063-K"},{"key":"e_1_2_1_91_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800280030004"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320540111","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320540111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T01:33:52Z","timestamp":1698111232000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320540111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3,15]]},"references-count":90,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,3,15]]}},"alternative-id":["10.1002\/ajmg.1320540111"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320540111","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,3,15]]}}}