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The sample consisted of 59 patients with schizophrenia (including seven with schizophreni\u2010form disorder), 54 patients with panic disorder (with or without agoraphobia), 29 comorbid patients with lifetime diagnoses of panic disorder and schizophrenia (or schizo\u2010phreniform disorder, 2 patients) and 109 controls, and their 1068 first\u2010degree relatives. Information from clinical performance, clinical and structured interviews, and from family history was joined to establish DSM\u2010III\u2010R diagnoses in patients and relatives. As expected, schizophrenia and panic disorder were found to be familial. The hypothesis, that the familial load for primary panic disorders distinguished schizophrenics (4.3%) and controls (0.9%), could be verified (<jats:italic>P<\/jats:italic> &lt; 0.01); the familial aggregation for primary panic disorders did not distinguish schizophrenics and subjects with panic disorder. However, the risk for schizophrenia was not enhanced in relatives of patients with panic disorder (0%) in comparison to controls (0.3%, <jats:italic>P<\/jats:italic> &gt; 0.05). The observed familial aggregation pattern of psychiatric disorders in relatives of schizophrenics, panic patients, comorbid patients, and controls refers to an etiological relation of schizophrenia and panic disorder, or at least to a relationship of subgroups of these disorders. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320600208","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:17:45Z","timestamp":1118513865000},"page":"127-132","source":"Crossref","is-referenced-by-count":24,"title":["Relation of schizophrenia and panic disorder: Evidence from a controlled family study"],"prefix":"10.1002","volume":"60","author":[{"given":"R.","family":"Heun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Maier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1987"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1001\/archpsyc.1977.01770220111013","article-title":"The family history method using diagnostic criteria. 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