{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T21:58:52Z","timestamp":1722290332356},"reference-count":61,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T00:00:00Z","timestamp":1160956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2007,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple lines of evidence suggest that schizophrenia results from aberrant neurodevelopment. The neurogenin1 gene (<jats:italic>neurog1<\/jats:italic>) consists of a single 1,666 bp exon that encodes a basic helix\u2010loop\u2010helix (bHLH) transcription factor that causes neuronal differentiation and induces cortical and glutamatergic differentiation programs. Because of its function and its location in 5q31.1, which has been linked to schizophrenia in multiple samples, we tested it for association with the disorder. We sequenced <jats:italic>neurog1<\/jats:italic> in 25 affected subjects from the Irish Study of High\u2010Density Schizophrenia Families. We observed a 5\u2032\u2010UTR SNP at position \u221260, already present in databases as rs8192558, and tested it along with rs2344485, rs8192559, and rs2344484. Narrow, intermediate, and broad diagnostic definitions were used. The major alleles of rs8192558 and rs2344484 were over\u2010transmitted to affected subjects using both Pedigree Disequilibrium Test (PDT) (0.01\u2009\u2264\u2009<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.06) and FBAT (0.02\u2009\u2264\u2009<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.07). A haplotype consisting of the major alleles of all four SNPs was significantly over\u2010transmitted in FBAT to the broad definition (<jats:italic>P<\/jats:italic>\u2009=\u20090.049), with trend significance to the narrow and intermediate definitions, and with trend significance in PDT. In confirmatory tests using 657 cases and 411 controls, this haplotype was slightly but not significantly over\u2010represented in cases (81% vs. 77%, <jats:italic>P<\/jats:italic>\u2009=\u20090.21). These results, along with a priori evidence for the involvement of <jats:italic>neurog1<\/jats:italic> in neurodevelopment, suggest that variants in <jats:italic>neurog1<\/jats:italic> might have a small effect on susceptibility to schizophrenia. This gene should be tested in additional and larger samples. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30423","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T11:42:21Z","timestamp":1161085341000},"page":"207-214","source":"Crossref","is-referenced-by-count":10,"title":["Association between the 5q31.1 gene neurogenin1 and schizophrenia"],"prefix":"10.1002","volume":"144B","author":[{"given":"Ayman H.","family":"Fanous","sequence":"first","affiliation":[]},{"given":"Xiangning","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Richard L.","family":"Amdur","sequence":"additional","affiliation":[]},{"given":"F. 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