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To see whether the familial correlation on language scores was accounted for by the familial correlation on non\u2010verbal IQ, residual language scores were calculated for each member of the sibpair based on a multiple regression equation using their IQ score as an explanatory or independent variable and controlling for the age and gender of the affected individual. These residual scores were then used to calculate intraclass correlations between affected sibs. This process was repeated using IQ as the dependent variable and language as a covariate. Within affected individuals there was a strong relation between non\u2010verbal IQ (as measured by the Leiter performance scale) and language (as measured by the Vineland Communication Scale). In addition, there was familial correlation between sibs on both measures. Evidence of familial aggregation on both non\u2010verbal IQ and language remained even after partialling out the effect of the covariates by regression analysis and by generalized estimating equation. These findings suggest that non\u2010verbal IQ and language in PDD may arise from independent genetic mechanisms. The implications of this finding for linkage analysis and for identifying genetically informative phenotypes are discussed. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30561","type":"journal-article","created":{"date-parts":[[2007,5,27]],"date-time":"2007-05-27T00:53:04Z","timestamp":1180227184000},"page":"3-9","source":"Crossref","is-referenced-by-count":18,"title":["Decomposing the autism phenotype into familial dimensions"],"prefix":"10.1002","volume":"147B","author":[{"given":"Peter","family":"Szatmari","sequence":"first","affiliation":[]},{"given":"Chantal","family":"M\u00e9rette","sequence":"additional","affiliation":[]},{"given":"Claudia","family":"Emond","sequence":"additional","affiliation":[]},{"given":"Lonnie","family":"Zwaigenbaum","sequence":"additional","affiliation":[]},{"given":"Marshall 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