{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T20:57:28Z","timestamp":1768078648930,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":6885,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1985,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adrenoleukodystrophy is a disorder of long\u2010chain fatty acid metabolism associated with adrenal cortical insufficiency and central nervous system demyelination. The central nervous system disease is unusual in that it is abrupt in onset and accompanied by a considerable infiltration of mononuclear inflammatory cells. To determine the nature of these inflammatory cells, immunocytochemical staining was carried out on the mononuclear cells in the brain and cerebrospinal fluid of patients with adrenoleukodystrophy. Monoclonal antibodies to T lymphocytes (T11), the helper\/inducer (T4) and cytotoxic\/suppressor (T8) subsets of T lymphocytes, B lymphocytes (B1), and monocyte\/macrophages (Ml or esterase) were used. Mononuclear cells in the perivascular cuffs of autopsy material from 4 patients were, on average, 59% T cells, 34% T4 cells, 16% T8 cells, 24% B cells, and 11% monocyte\/macrophages. Cerebrospinal fluid from 8 of 10 patients had increased IgG concentrations. Mononuclear cells in the cerebrospinal fluid of 6 patients with active disease were, on average, 61% T cells, 40% T4 cells, 16% T8 cells, 3% B cells, and 18% monocyte\/macrophages. This distribution of cells is similar to that found in the central nervous system during a cellular immune response and suggests the possibility that one component of this disease is immunologically mediated.<\/jats:p>","DOI":"10.1002\/ana.410180606","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:27:02Z","timestamp":1104600422000},"page":"660-664","source":"Crossref","is-referenced-by-count":87,"title":["Identification of the inflammatory cells in the central nervous system of patients with adrenoleukodystrophy"],"prefix":"10.1002","volume":"18","author":[{"given":"Diane E.","family":"Griffin","sequence":"first","affiliation":[]},{"given":"Hugo W.","family":"Moser","sequence":"additional","affiliation":[]},{"given":"Querubin","family":"Mendoza","sequence":"additional","affiliation":[]},{"given":"Thomas R.","family":"Moench","sequence":"additional","affiliation":[]},{"given":"Susan","family":"O'Toole","sequence":"additional","affiliation":[]},{"given":"Ann B.","family":"Moser","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00691593"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(83)90201-0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(83)90037-5"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1983.tb04748.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110628"},{"key":"e_1_2_1_8_2","first-page":"42","article-title":"Poliomyelitis: immunoglobulin\u2010containing cells in the central nervous system in acute and convalescent phases of the human disease","volume":"40","author":"Esiri MM","year":"1980","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1980.tb00199.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1984.tb00392.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1977.tb00367.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90310-1"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(84)90026-6"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.5.575"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.4049\/jimmunol.131.6.2805","article-title":"Identification and quantitation of T lymphocyte subsets found in the spinal cord of the Lewis rat during acute experimental allergic encephalomelitis","volume":"131","author":"Hickcy WF","year":"1983","journal-title":"J Immunol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/29.4.6166661"},{"key":"e_1_2_1_17_2","first-page":"359","volume-title":"Vitro Methods in Cell\u2010Mediated and Tumor Immunity","author":"Koski IR","year":"1976"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(80)90169-0"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(65)90004-2"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240190403"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.159.1.77"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.10.1241"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410070607"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160603"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1976.tb04350.x"},{"key":"e_1_2_1_26_2","first-page":"259","volume-title":"Cellular Functions in Immunity and Inflammation","author":"Oppenheim JJ","year":"1981"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.4.1227"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.155.1.17"},{"key":"e_1_2_1_29_2","first-page":"353","article-title":"A correlative study of the adrenal cortex in adrenoleukodystrophy. Evidence for a fatal intoxication with very long chain saturated fatty acids","volume":"3","author":"Powers JM","year":"1980","journal-title":"Invest Cell Pathol"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1983.tb00826.x"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1975.00490510033001"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)91161-0"},{"key":"e_1_2_1_33_2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/oxfordjournals.bmb.a071391","article-title":"Laboratory diagnosis of multiple sclerosis: immunological and biochemical aspects","volume":"33","author":"Thompson EJ","year":"1977","journal-title":"Br Med Bull"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(83)90036-X"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198301203080307"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410180606","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410180606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T06:37:47Z","timestamp":1695796667000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410180606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,12]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1985,12]]}},"alternative-id":["10.1002\/ana.410180606"],"URL":"https:\/\/doi.org\/10.1002\/ana.410180606","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,12]]}}}