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In 10 patients the tumor evolved from a low\u2010grade lesion. Seven patients, including 2 patients with neurofibromatosis, developed multiple primary malignant neoplasms. The median time to tumor progression after surgery was 31 weeks, with local recurrence representing the mode of treatment failure in nearly all patients. Notable clinical features included symptomatic leptomeningeal metastasis (13 patients) and intratumoral hemorrhage (9 patients). The estimated median survival time for all 50 patients was 98 weeks, with a 3\u2010year survival rate of 32%. A trend toward longer survival was seen in patients 12 years of age or younger at diagnosis. There was no apparent correlation between survival and tumor histology or tumor location. Recommendations for management are presented.<\/jats:p>","DOI":"10.1002\/ana.410220312","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:49:54Z","timestamp":1104601794000},"page":"355-364","source":"Crossref","is-referenced-by-count":69,"title":["Supratentorial malignant gliomas in childhood: A review of fifty cases"],"prefix":"10.1002","volume":"22","author":[{"given":"Edward J.","family":"Dropcho","sequence":"first","affiliation":[]},{"given":"Jeffrey H.","family":"Wisoff","sequence":"additional","affiliation":[]},{"given":"Russell W.","family":"Walker","sequence":"additional","affiliation":[]},{"given":"Jeffrey C.","family":"Allen","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"171","article-title":"Nine brain tumors as a late effect in children \u201ccured\u201d of acute lymphoblastic leukemia (ALL) from a single protocol study (141) 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