{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:06:03Z","timestamp":1770717963725,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":4998,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1991,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Using the polymerase chain reaction, we quantitated the amount of human T\u2010lymphotropic virus type I (HTLV\u2010I) proviral DNA in peripheral blood mononuclear cells from 18 patients with HTLV\u2010I\u2013associated myelopathy\/tropical spastic paraparesis; 17 HTLV\u2010I carriers without HTLV\u2010I\u2013associated myelopathy\/tropical spastic paraparesis, with or without other autoimmune or inflammatory diseases; and 19 seronegative control subjects. The HTLV\u2010I proviral DNA was 10\u2010 to 100\u2010fold higher in the patients and in the HTLV\u2010I carriers without HAM\/TSP who had autoimmune or inflammatory diseases than in the carriers without autoimmune or inflammatory diseases. The patients who had had onset of myelopathy at a younger age (15 to 39 years) had an extremely high level of HTLV\u2010I proviral DNA in the early phase, as compared with findings in those with a late onset of myelopathy (at 44 to 61 years). The large increase in HTLV\u2010I proviral DNA in peripheral blood mononuclear cells is presumably closely related to the development of autoimmune or inflammatory processes in HTLV\u2010I carriers, including HTLV\u2010I\u2013associated myelopathy\/tropical spastic paraparesis.<\/jats:p>","DOI":"10.1002\/ana.410290214","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T11:55:43Z","timestamp":1104580543000},"page":"194-201","source":"Crossref","is-referenced-by-count":116,"title":["Increased HTLV\u2010I proviral DNA in HTLV\u2010I\u2013associated myelopathy: A quantitative polymerase chain reaction 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