{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:14:19Z","timestamp":1770218059102,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":4359,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1992,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The genetic mutation of X\u2010linked recessive bulbospinal neuronopathy is amplification of a polymorphic tandem CAG repeat in the androgen receptor gene. We studied this CAG repeat in 26 Japanese patients from 21 families with X\u2010linked recessive bulbospinal neuronopathy. The number of CAG repeats was significantly correlated with the age at onset of limb muscular weakness (<jats:italic>r<\/jats:italic> = \u22120.596, <jats:italic>p<\/jats:italic> &lt; 0.001) and age\u2010adjusted scored disability (<jats:italic>r<\/jats:italic> = 0.446, <jats:italic>p<\/jats:italic> &lt; 0.03). The length of the CAG repeat therefore seems to be a determinant factor of clinical severity.<\/jats:p>","DOI":"10.1002\/ana.410320517","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T12:17:32Z","timestamp":1104581852000},"page":"707-710","source":"Crossref","is-referenced-by-count":156,"title":["Severity of X\u2010linked recessive bulbospinal neuronopathy correlates with size of the tandem cag repeat in androgen receptor gene"],"prefix":"10.1002","volume":"32","author":[{"given":"Manabu","family":"Doyu","sequence":"first","affiliation":[]},{"given":"Gen","family":"Sobue","sequence":"additional","affiliation":[]},{"given":"Eiichiro","family":"Mukai","sequence":"additional","affiliation":[]},{"given":"Teruhiko","family":"Kachi","sequence":"additional","affiliation":[]},{"given":"Takeshi","family":"Yasuda","sequence":"additional","affiliation":[]},{"given":"Terunori","family":"Mitsuma","sequence":"additional","affiliation":[]},{"given":"Akira","family":"Takahashi","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.18.7.671"},{"key":"e_1_2_1_3_2","first-page":"255","article-title":"Clinical features of bulbar\u2010spinal muscular atrophy","volume":"20","author":"Mukai E","year":"1980","journal-title":"Clin Neurol (Tokyo)"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.45.11.1012"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/112.1.209"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","unstructured":"WarnerCL GriffinJE WilsonJD et al. X\u2010linked spinomuscular atrophy: a kindred with associated abnormal androgen receptor binding.Neurology1992(in press)","DOI":"10.1212\/WNL.42.11.2181"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/352077a0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.867053"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198107000-00007"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)52466-2"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90283-5"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90397-H"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.252.5009.1097"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.252.5009.1179"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/355545a0"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/355547a0"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/355548a0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90154-5"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90729-M"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410320517","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410320517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T06:17:34Z","timestamp":1698128254000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410320517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,11]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,11]]}},"alternative-id":["10.1002\/ana.410320517"],"URL":"https:\/\/doi.org\/10.1002\/ana.410320517","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,11]]}}}