{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:26:34Z","timestamp":1767666394803},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":4055,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Striatal <jats:sup>18<\/jats:sup>F\u20106\u2010fluorodopa (FD) uptake constants were measured by positron emission tomography in (1) normal cynomolgus monkeys and (2) a series of cynomolgus and rhesus monkeys that had received intracarotid infusions of 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP). After the animals were killed, the number and average size of dopaminergic neurons in the substantia nigra pars compacta were measured. Striatal levels of dopamine and its metabolites, and the striatal activities of the dopaminergic synthetic enzymes, were also determined. The striatal FD uptake constants showed highly significant positive correlations with both number and size of dopaminergic neurons, indicating atrophy of surviving neurons in MPTP\u2010treated animals. The uptake constants also showed significant positive correlations with striatal levels of dopamine, total catecholamines, and the activities of the synthetic enzymes. Both histochemical and biochemical data on tyrosine hydroxylase suggested some contralateral enzyme loss in these MPTP\u2010treated monkeys, as well as decreased enzyme activity in surviving neurons on the lesioned side. However, residual enzyme activities were apparently not rate limiting to striatal FD uptake. It is concluded that PET\u2010FD measurements by positron emission tomography provide a good index of the integrity of the nigrostriatal pathway.<\/jats:p>","DOI":"10.1002\/ana.410340306","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:25:42Z","timestamp":1104539142000},"page":"331-338","source":"Crossref","is-referenced-by-count":141,"title":["Correlation of striatal fluorodopa uptake in the MPTP Monkey with dopaminergic indices"],"prefix":"10.1002","volume":"34","author":[{"given":"Brian D.","family":"Pate","sequence":"first","affiliation":[]},{"given":"T.","family":"Kawamata","sequence":"additional","affiliation":[]},{"given":"T.","family":"Yamada","sequence":"additional","affiliation":[]},{"given":"E. G.","family":"McGeer","sequence":"additional","affiliation":[]},{"given":"K. A.","family":"Hewitt","sequence":"additional","affiliation":[]},{"given":"B. J.","family":"Snow","sequence":"additional","affiliation":[]},{"given":"T. J.","family":"Ruth","sequence":"additional","affiliation":[]},{"given":"D. B.","family":"Calne","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/305137a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(86)90403-0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(92)90339-Q"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410260407"},{"key":"e_1_2_1_6_2","first-page":"964","article-title":"Decline of the L\u20106\u2010[F\u201018]fluorodopa rate constant K\n                  i versus age","volume":"33","author":"Cordes M","year":"1992","journal-title":"J Nucl Med"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280611"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.8.853"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1990.tb00926.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.1.199"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1992.tb04005.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(85)90135-2"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1990.00530080052010"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/317246a0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490270408"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199203000-00013"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(86)90191-6"},{"key":"e_1_2_1_18_2","first-page":"167","volume-title":"Advances in neurology","author":"Chiueh CC","year":"1986"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300207"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280412"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300106"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2105529"},{"key":"e_1_2_1_23_2","unstructured":"WidnerH TetrudJW RehncronaS et al . Bilateral fetal mesencephalic grafting in two patients with MPTP\u2010induced parkinsonism.N Engl J Med1992(in press)"},{"issue":"1","key":"e_1_2_1_24_2","first-page":"264","article-title":"In\u2010vivo studies of presynaptic dopaminergic function in non\u2010human primates by PET\u2010FD scanning","volume":"40","author":"Pate BD","year":"1990","journal-title":"Neurology"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(86)90431-5"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.1983.4332361"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0883-2889(88)90100-1"},{"key":"e_1_2_1_28_2","first-page":"1246","article-title":"The reproducibility of striatal uptake data obtained with positron emission tomography and fluorine\u201018\u2010L\u20106\u2010fluorodopa tracer in non\u2010human primates","volume":"32","author":"Pate BD","year":"1991","journal-title":"J Nucl Med"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1990.tb02322.x"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)91470-9"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90665-3"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00427222"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/34.11.2430009"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(86)90079-5"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410210603"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090940210"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90212-1"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.14.4546"},{"key":"e_1_2_1_40_2","unstructured":"PateBD McGeerEG SnowBJ et al .Unilateral intracarotid infusions of MPTP produce asymmetric bilateral depression of dopamine synthetic enzymes. Tenth International Symposium on Parkinson's Disease Tokyo Japan 1991"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1139\/o67-185"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.10.040170.001421"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530160025009"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050190062015"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490270408"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90037-V"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410340306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410340306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T05:43:44Z","timestamp":1698212624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410340306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,9]]}},"alternative-id":["10.1002\/ana.410340306"],"URL":"https:\/\/doi.org\/10.1002\/ana.410340306","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,9]]}}}