{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T14:00:37Z","timestamp":1774792837691,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":3568,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As part of a community\u2010based study of Alzheimer's disease (AD) in the African\u2010American population age 65 and over, we have determined apolipoprotein E (Apo E) genotypes in 85 subjects (31 AD patients and 54 controls). The \u20ac4 allele of Apo E was strongly associated with AD in this population sample. The \u20ac allele frequency in AD patients was 40.3% compared with 13.9% in the control group, and 22.6% of the AD patients were homozygous for this allele compared with 3.7% of the control subjects (<jats:italic>p<\/jats:italic> = 0.01). This study extends the association of Apo E\u2010\u22084 and AD to nonwhite populations and provides further evidence that the observed allelic association is biologically relevant.<\/jats:p>","DOI":"10.1002\/ana.410370123","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:12:48Z","timestamp":1104595968000},"page":"118-120","source":"Crossref","is-referenced-by-count":95,"title":["Apolipoprotein E genotypes and Alzheimer's disease in a community study of elderly African Americans"],"prefix":"10.1002","volume":"37","author":[{"given":"H. C.","family":"Hendrie","sequence":"first","affiliation":[]},{"given":"K. S.","family":"Hall","sequence":"additional","affiliation":[]},{"given":"S.","family":"Hui","sequence":"additional","affiliation":[]},{"given":"F. W.","family":"Unverzagt","sequence":"additional","affiliation":[]},{"given":"C. E.","family":"Yu","sequence":"additional","affiliation":[]},{"given":"D. K.","family":"Lahiri","sequence":"additional","affiliation":[]},{"given":"A.","family":"Sahota","sequence":"additional","affiliation":[]},{"given":"M.","family":"Farlow","sequence":"additional","affiliation":[]},{"given":"B.","family":"Musick","sequence":"additional","affiliation":[]},{"given":"A.","family":"Brashear","sequence":"additional","affiliation":[]},{"given":"V. E.","family":"Burdine","sequence":"additional","affiliation":[]},{"given":"B. O.","family":"Osuntokun","sequence":"additional","affiliation":[]},{"given":"A. O.","family":"Ogunniyi","sequence":"additional","affiliation":[]},{"given":"O.","family":"Gureje","sequence":"additional","affiliation":[]},{"given":"O.","family":"Baiyewu","sequence":"additional","affiliation":[]},{"given":"G. D.","family":"Schellenberg","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.8.1467"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91709-U"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.2.339"},{"key":"e_1_2_1_6_2","first-page":"643","article-title":"Apolipoprotein E: risk factor for Alzheimer disease","volume":"54","author":"Tsai MS","year":"1994","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_7_2","first-page":"49","article-title":"Ferrell RE. Genetic studies of human apolipoproteins. VI. Common polymorphism of apolipoprotein E in blacks","volume":"7","author":"Kamboh MI","year":"1989","journal-title":"Dis Markers"},{"key":"e_1_2_1_8_2","first-page":"352","article-title":"Crosscultural studies in Alzheimer's disease","volume":"2","author":"Osuntokun BO","year":"1992","journal-title":"Ethnic Dis"},{"key":"e_1_2_1_9_2","first-page":"1","article-title":"The development of a dementia screening interview in two distinct languages","volume":"3","author":"Hall KS","year":"1993","journal-title":"Int J Methods Psychiatry Res"},{"key":"e_1_2_1_10_2","first-page":"97","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1987"},{"key":"e_1_2_1_11_2","first-page":"F00","volume-title":"International statical classification of diseases and related health problems. 10th revision (ICD\u201010)","author":"World Health Organization","year":"1992"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(88)90130-9"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340527"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.8.1.1"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0194-29"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91704-P"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410370123","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410370123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T23:24:00Z","timestamp":1698362640000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410370123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1002\/ana.410370123"],"URL":"https:\/\/doi.org\/10.1002\/ana.410370123","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}