{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T13:46:51Z","timestamp":1770472011998,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":3112,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1996,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many studies have demonstrated a strong association between the presence of one or two \u03b54 alleles and Alzheimer's disease (AD), although few data are available on the apolipoprotein E (APOE) \u03b54 frequencies at the preclinical stages of AD. Thus, with a view to determining whether APOE genotyping could be useful in the early detection of AD, we determined the APOE allele frequencies in patients with memory complaints without dementia (age\u2010related memory decline, ARMD). We found an APOE \u03b54 allele frequency of 0.315 in the ARMD group, similar to 0.293 in the AD group, in contrast to 0.057 in the control group. Significant differences (<jats:italic>t<\/jats:italic>= \u22122.91, <jats:italic>df<\/jats:italic>=25,p=0.008) were found between the Alzheimer's Disease Assessment Scale (ADAS) total scores in the ARMD patients with at least one \u03b54 allele (mean=24.2) compared with the ARMD patients without the \u03b54 allele (mean= 14.7). Our results suggest that the patients with memory complaints, a high ADAS score, and the presence of one or two APOE\u20104 alleles could be at high risk for developing AD. Thus, we propose that genotyping in conjunction with the ADAS scale may prove useful as diagnostic markers of AD in the presymptomatic stages.<\/jats:p>","DOI":"10.1002\/ana.410390419","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:33:31Z","timestamp":1104597211000},"page":"548-551","source":"Crossref","is-referenced-by-count":39,"title":["High apolipoprotein E \u03b54 allele frequency in Age\u2010related memory decline"],"prefix":"10.1002","volume":"39","author":[{"given":"Rafael","family":"Blesa","sequence":"first","affiliation":[]},{"given":"Rosa","family":"Adroer","sequence":"additional","affiliation":[]},{"given":"Pilar","family":"Santacruz","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Ascaso","sequence":"additional","affiliation":[]},{"given":"Eduardo","family":"Tolosa","sequence":"additional","affiliation":[]},{"given":"Rafael","family":"Oliva","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.5.1977"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.8.1467"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91705-Q"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90070-8"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)11480-K"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360614"},{"key":"e_1_2_1_8_2","unstructured":"MayeuxR SternY OttmanRet al.The apolipoprotein \u03b54 allele in patients with Alzheimer's disease. 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