{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:57:50Z","timestamp":1773662270896,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":2260,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1998,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several groups have identified mitochondrial complex I deficiency in Parkinson's disease (PD) substantia nigra and in platelets. A search for any mitochondrial DNA (mtDNA) mutation underlying this defect has not yet produced any consistent result. We have made use of a mtDNA\u2010less (\u03bc<jats:sup>o<\/jats:sup>) cell line to determine if the complex I deficiency follows the genomic transplantation of platelet mtDNA. From a preselected group of PD patients with low platelet complex I activity, 7 patients were used for detailed study. All 7 patients were used for mixed cybrid analysis and demonstrated a selective 25% deficiency of complex I activity. Individual clonal analysis of A549 \u03bc<jats:sup>O<\/jats:sup>\/PD platelet fusion cybrids from 1 of the patients expressed combined complex I and IV deficiencies with 25% and 20% decreased activities in the PD clones, respectively. Histocytochemical, immunocytochemical, and cellular functional imaging studies of these clones showed the cells within the clones were heterogeneous with respect to cytochrome <jats:bold>c<\/jats:bold> oxidase (COX) function, COX I content, and mitochondrial respiratory chain activity. These results are in agreement with a previous study and support the proposition that an mtDNA abnormality may underlie the mitochondrial defect in at least a proportion of PD patients. This \u03bc<jats:sup>o<\/jats:sup> technology may serve as a means to identify the subgroup of PD patients in whom an mtDNA defect may contribute to development of the disease.<\/jats:p>","DOI":"10.1002\/ana.410440207","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:21:18Z","timestamp":1104592878000},"page":"177-186","source":"Crossref","is-referenced-by-count":249,"title":["Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease"],"prefix":"10.1002","volume":"44","author":[{"given":"M.","family":"Gu","sequence":"first","affiliation":[]},{"given":"J. M.","family":"Cooper","sequence":"additional","affiliation":[]},{"given":"J. W.","family":"Taanman","sequence":"additional","affiliation":[]},{"given":"A. H. 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