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Transmission electron microscopy of treated cells showed microfilament bundles extending between adjacent granules within the cytoplasm and between granules and the plasma membrane. Tiny dense projections (beads) 8\u201012 nm in diameter were observed along segments of the cytoplasmic surface of the plasma membrane with a periodicity of 20\u201330 nm. These beads were observed on the plasma membrane only in the vicinity of intra\u2010 or extracytoplasmic granules. The structural relationships of the beads with the plasma membrane micro\u2010filaments suggest they play a role in the process of ionophore\u2010induced granule release from polymorphonuclear leukocytes.<\/jats:p>","DOI":"10.1002\/ar.1091890205","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T12:07:05Z","timestamp":1109419625000},"page":"177-185","source":"Crossref","is-referenced-by-count":5,"title":["Granule release by polymorphonuclear leukocytes treated with the lonophore A23187"],"prefix":"10.1002","volume":"189","author":[{"given":"Philip L.","family":"Sannes","sequence":"first","affiliation":[]},{"given":"Harvey L.","family":"Bank","sequence":"additional","affiliation":[]},{"given":"Patrick L.","family":"Moore","sequence":"additional","affiliation":[]},{"given":"Samuel S.","family":"Spicer","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,2,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.62.3.647"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(76)80507-8"},{"issue":"21","key":"e_1_2_1_4_1","first-page":"1093","article-title":"Neutrophil actin dysfunction and abnormal neutrophil behavior. 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