{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:27:18Z","timestamp":1773808038110,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,8]],"date-time":"2005-02-08T00:00:00Z","timestamp":1107820800000},"content-version":"vor","delay-in-days":5731,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1989,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The production of type I collagen by fibroblasts, odontoblasts, and osteoblasts is reviewed on the basis of results obtained by electron microscopy, 3H\u2010proline radioautography, and immunostaining for type I procollagen.<\/jats:p><jats:p>In the three cell types, the percursors of type I collagen are processed along the rough endocplasmic reticulum (rER)\u2010Golgic\u2010secretory granule pathway in the same manner as secretory proteins, but the available evidence suggests a few special features: (1) From the rER site of synthesis, the initial collagen procursors, known as pro\u2010alpha chains, are transported to the Golgi apparatus within tubular structures, referred to as intermediate tubules, rather than within vesicles. (2) The pro\u2010alpha chains coil into a triple helix within spherical distensions present along the saccules on the cis side of Golgi stacks. (3) The resulting procollagens are fairly raigid and form bundles that cause spherical distensions to lengthen into cylindrical ones, whereas by an unknown mechanism these distensions become part of the saccules on the trans\u2010side of Golgi stacks. (4) The procollagen\u2010containing cylindrical distensions are resleased from trans\u2010saccules to become secretory granules, and some procollagen material finds its way into lysosomes. (5) The secretory granules release their procollagen content by exocytosis at the cell surface. (6) The released procollagen is transformed into collagen before or, more probably, after associating with the surface of a collagen fibril.<\/jats:p>","DOI":"10.1002\/ar.1092240204","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T22:31:28Z","timestamp":1109457088000},"page":"123-138","source":"Crossref","is-referenced-by-count":105,"title":["Synthesis and secretion of collagen by cells of connective tissue, bone, and dentin"],"prefix":"10.1002","volume":"224","author":[{"given":"C. P.","family":"Leblond","sequence":"first","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,2,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.43.070174.003031"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.20.3.473"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091990403"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092010402"},{"key":"e_1_2_1_6_1","first-page":"148","volume-title":"Scientific American Books","author":"Darnell J.","year":"1986"},{"key":"e_1_2_1_7_1","first-page":"533","article-title":"Collagen fibrillogenesis: a mechanism of structural biology","volume":"87","author":"Fleischmajer R.","year":"1986","journal-title":"J. Invest. Dermatol."},{"key":"e_1_2_1_8_1","first-page":"479","volume-title":"The Role of Extracellular Matrix in Development","author":"Gross J.","year":"1984"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/27.7.89154"},{"key":"e_1_2_1_10_1","first-page":"53","volume-title":"The Biological Mechanisms of Tooth Eruption and Root Resorption","author":"Marchi F.","year":"1988"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001680206"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.98.5.1705"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(81)80064-0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-74-3-333"},{"key":"e_1_2_1_15_1","first-page":"179","article-title":"An ultrastructrual study of collagen degration in human involuting uterus","volume":"23","author":"Okamura H.","year":"1976","journal-title":"Acta Obstey. Gynaecol. Jpn."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197907053010104"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00341524"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1980.tb00260.x"},{"key":"e_1_2_1_19_1","first-page":"401","article-title":"Morphological studies of fibrocytes in connective tissue undergoing rapid remodelling","volume":"112","author":"Ten Cate A. R.","year":"1972","journal-title":"J. Anat."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091820102"},{"key":"e_1_2_1_21_1","first-page":"513","volume-title":"The Role of Extracellular Matrix in Development","author":"Trelstad R. L.","year":"1984"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(79)90166-0"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091480306"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(72)90238-5"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.16.1.1"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-648360-4.50022-5"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(77)80089-0"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.60.1.92"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/29.7.6167609"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.1092240204","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.1092240204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T10:48:37Z","timestamp":1697971717000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ar.1092240204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,6]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,6]]}},"alternative-id":["10.1002\/ar.1092240204"],"URL":"https:\/\/doi.org\/10.1002\/ar.1092240204","archive":["Portico"],"relation":{},"ISSN":["0003-276X","1097-0185"],"issn-type":[{"value":"0003-276X","type":"print"},{"value":"1097-0185","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,6]]}}}