{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T12:42:08Z","timestamp":1768740128159,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T00:00:00Z","timestamp":1106697600000},"content-version":"vor","delay-in-days":4349,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1993,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lactating mammary glands fixed by perfusion with 5% glutaraldehyde subsequently were postfixed with potassium ferrocyanide reduced osmium or were treated with tannic acid. Stained thin sections were examined with the electron microscope and stereopairs were prepared. The distribution of casein submicelles was analyzed in the various components of the Golgi apparatus. The Golgi stacks were composed of five or six elements, all of which contained casein submicelles 20 nm in diameter. The cis\u2010tubular network or cis\u2010element, as well as the underlying three or four midsaccules, showed these casein submicelles either attached to their membrane or free in the lumen. The trans\u2010most element of the stacks formed distended prosecretory granules in which both isolated or clustered casein submicelles were suspended in an electron\u2010lucent fluid. These micellar aggregates increased in size and became progressively more compact to form spherical dense bodies or casein micelles, in which the individual 20 nm particles could easily be resolved. Casein micelles were seen in secretory granules in addition to a wispy material of low density. The numerous small spherical vesicles (80 nm or larger) seen on the cis, lateral, or trans aspects of the stacks did not appear to contain free casein submicelles. This raises questions regarding the role of these vesicles in the transport of casein macromolecules through the Golgi stacks. It was noticeable that in this Golgi apparatus a trans\u2010Golgi network was limited to a few small residual tubules free from casein submicelles. It thus appears that the greater part of the trans\u2010most Golgi element gives rise to the large prosecretory granules. After leaving the Golgi region and prior to exocytosis, the secretory granules often fuse to form larger granules before exocytosis. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.1092350305","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T19:35:32Z","timestamp":1109446532000},"page":"363-373","source":"Crossref","is-referenced-by-count":68,"title":["Transport of casein submicelles and formation of secretion granules in the golgi apparatus of epithelial cells of the lactating mammary gland of the rat"],"prefix":"10.1002","volume":"235","author":[{"given":"Y.","family":"Clermont","sequence":"first","affiliation":[]},{"given":"L.","family":"Xia","sequence":"additional","affiliation":[]},{"given":"A.","family":"Rambourg","sequence":"additional","affiliation":[]},{"given":"J. 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