{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T04:01:45Z","timestamp":1775793705799,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,3,7]],"date-time":"2002-03-07T00:00:00Z","timestamp":1015459200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The Pediatric Quality of Life Inventory (PedsQL) is a modular instrument designed to measure health\u2010related quality of life (HRQOL) in children and adolescents ages 2\u201318 years. The 23\u2010item PedsQL 4.0 Generic Core Scales are multidimensional child self\u2010report and parent proxy\u2010report scales developed as the generic core measure to be integrated with the PedsQL disease\u2010specific modules. The 22\u2010item PedsQL 3.0 Rheumatology Module was designed to measure pediatric rheumatology\u2013specific HRQOL. This study was undertaken to demonstrate the reliability, validity, and responsiveness of the PedsQL 4.0 Generic Core Scales and the PedsQL 3.0 Rheumatology Module in pediatric rheumatology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The 4 PedsQL 4.0 Generic Core Scales (physical, emotional, social, and school functioning) and the 5 PedsQL 3.0 Rheumatology Module scales (pain and hurt, daily activities, treatment, worry, and communication) were administered to 231 children and 244 parents (271 subjects accrued overall) recruited from a pediatric rheumatology clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Internal consistency reliability for the PedsQL Generic Core total scale score (\u03b1 = 0.91 for child self report, \u03b1 = 0.93 for parent proxy report), physical health summary score (\u03b1 = 0.87 for child self report, \u03b1 = 0.89 for parent proxy report), and psychosocial health summary score (\u03b1 = 0.86 for child self report, \u03b1 = 0.90 for parent proxy report) were acceptable for group comparisons. The Rheumatology Module scales also demonstrated acceptable reliability for group comparisons (\u03b1 = 0.75\u20130.86 for child self report, \u03b1 = 0.82\u20130.91 for parent proxy report). Validity was demonstrated using the known\u2010groups method. The PedsQL distinguished between healthy children and children with rheumatic diseases as a group. The responsiveness of the PedsQL was demonstrated through patient change over time as a result of clinical intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results demonstrate the reliability, validity, and responsiveness of the PedsQL 4.0 Generic Core Scales and the PedsQL 3.0 Rheumatology Module in pediatric rheumatology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.10095","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T12:00:41Z","timestamp":1033905641000},"page":"714-725","source":"Crossref","is-referenced-by-count":457,"title":["The PedsQL\u2122 in pediatric rheumatology: Reliability, validity, and responsiveness of the Pediatric Quality of Life Inventory\u2122 generic core scales and rheumatology module"],"prefix":"10.1002","volume":"46","author":[{"given":"James W.","family":"Varni","sequence":"first","affiliation":[]},{"given":"Michael","family":"Seid","sequence":"additional","affiliation":[]},{"given":"Tara","family":"Smith Knight","sequence":"additional","affiliation":[]},{"given":"Tasha","family":"Burwinkle","sequence":"additional","affiliation":[]},{"given":"Joy","family":"Brown","sequence":"additional","affiliation":[]},{"given":"Ilona S.","family":"Szer","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2002,3,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/0470846283"},{"key":"e_1_2_5_3_2","unstructured":"1996 Lippincott\u2010Raven Philadelphia B Spilker Quality of life and pharmacoeconomics in clinical trials"},{"key":"e_1_2_5_4_2","first-page":"33","article-title":"Pediatric health\u2010related quality of life measurement technology: a guide for health care decision makers","volume":"6","author":"Varni JW","year":"1999","journal-title":"J Clin Outcomes Meas"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008928518577"},{"key":"e_1_2_5_6_2","volume-title":"Constitution of the World Health Organization basic document","author":"World Health Organization","year":"1948"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0889-857X(21)00140-X","article-title":"Evaluation and management of pain in children with rheumatic diseases","volume":"17","author":"Varni JW","year":"1991","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)40056-8"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90016-4"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780321107"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340713"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780371209"},{"key":"e_1_2_5_13_2","first-page":"8","article-title":"Whose life is it anyway? 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