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Greater inflammation was accompanied by augmented passage of each protein across the synovial membrane, and by proportionately greater increase in permeability to larger proteins. In classic rheumatoid arthritis, synovial IgM and IgG concentrations were higher than predicted from the above\u2010described interrelationships, suggesting local immunoglobulin synthesis.<\/jats:p>","DOI":"10.1002\/art.1780140503","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T16:02:18Z","timestamp":1171468938000},"page":"560-570","source":"Crossref","is-referenced-by-count":149,"title":["Permeability of human synovial membrane to plasma proteins. 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