{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T22:59:27Z","timestamp":1762297167619},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":11770,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1973,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prostaglandin E<jats:sub>1<\/jats:sub> (PGE<jats:sub>1<\/jats:sub>) suppressed acute carrageenan\u2010induced inflammation and chronic joint inflammation characteristic of adjuvant disease in the rat. Placement of PGE<jats:sub>1<\/jats:sub> into subcutaneous air blebs at the time of carrageenan injection retarded movement of polymorphonuclear leukocytes into the focus of inflammation and produced a concentration\u2010dependent reduction in exudate \u03b2\u2010glucuronidase and lactate dehydrogenase activities, an effect also observed in adrenalectomized rats. PGE<jats:sub>2<\/jats:sub> also significantly reduced enzyme activities released into inflammatory exudates. Ultrastructural studies indicated that carrageenan was ingested by invading polymorphs and enclosed within phagocytic vacuoles, the membranes of which subsequently ruptured. More lysosomes remained intact after carrageenan uptake in bleb leukocytes from PGE<jats:sub>1<\/jats:sub>\u2010treated than from control rats and there was no loss of phagosomal membrane integrity in cells from treated rats. Treatment of adrenalectomized rats with PGE<jats:sub>1<\/jats:sub> (300 \u03bcg twice daily) prevented adjuvant\u2010induced systemic arthritis, reduced the acute inflammatory reaction at the site of adjuvant injection, and reduced the number of circulating small lymphocytes. Together, these two sets of experiments suggest that pharmacologic doses of prostaglandins are anti\u2010inflammatory in acute and chronic models, and that the effect is not mediated entirely by stimulation of the pituitary and\/or adrenal glands.<\/jats:p>","DOI":"10.1002\/art.1780160505","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T16:16:50Z","timestamp":1171469810000},"page":"606-618","source":"Crossref","is-referenced-by-count":84,"title":["Suppression of acute and chronic inflammation in adrenalectomized rats by pharmacologic amounts of prostaglandins"],"prefix":"10.1002","volume":"16","author":[{"given":"Robert B.","family":"Zurier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Hoffstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Weissmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.41.070172.001113"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.12.040172.001533"},{"key":"e_1_2_1_4_2","first-page":"321","volume-title":"Prostaglandin Symposium of the Worcester Foundation for Experimental Biology","author":"Kaley G","year":"1968"},{"key":"e_1_2_1_5_2","first-page":"280","article-title":"Prostaglandin on cutaneous vasculature.","volume":"51","author":"Solomon LM","year":"1968","journal-title":"J Invest Dermatol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2340\/0001555549251261","article-title":"Cutaneous vascular reactions to prostaglandins in healthy subjects and in patients with urticaria and atopic dermatitis.","volume":"49","author":"Juhlin L","year":"1969","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1971.tb09934.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1971.tb02527.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/newbio231232a0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/newbio231235a0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1182\/blood.V35.4.514.514","article-title":"Effects of prostaglandins, epinephrine and NaF on human leucocyte, platelet and liver adenyl cyclase.","volume":"35","author":"Scott RE","year":"1970","journal-title":"Blood"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106564"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"149s","DOI":"10.1084\/jem.134.3.149","article-title":"Mechanisms of lysosomal enzyme release from leucocytes exposed to immune complexes and other particles.","volume":"134","author":"Weissmann G","year":"1971","journal-title":"J Exp Med"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.3.844"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.4049\/jimmunol.107.4.1131","article-title":"The immediate allergic response:in vitro action of cyclic AMP\u2010active and other drugs on the two stages of histamine release.","volume":"107","author":"Lichtenstein LM","year":"1971","journal-title":"J Immunol"},{"key":"e_1_2_1_16_2","unstructured":".TauberAI KalinerM StechschulteDJ AustenKF: Immunologic release of histamine and slow reacting substances and anaphylaxis from human lung. 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