{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:07:14Z","timestamp":1777622834082,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5790,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1990,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined the effect of interleukin\u20101 (IL\u20101) administration on a mild and transient inflammatory response in the knees of mice injected intraarticularly with methylated bovine serum albumin (mBSA). Injection of mBSA on day 0 into nonsensitized mice caused a weak inflammatory response confined to the infrapatellar fat pads and involved infiltration by mononuclear cells, neutrophils, and eosinophils. The response developed between days 4 and 7 and resolved by day 28. No erosion of cartilage or subchondral bone was seen. In contrast, mBSA\u2010treated mice injected with recombinant human IL\u20101\u03b2 subcutaneously in the ipsilateral footpad on days 0\u20133 developed a severe monarticular arthritis in the antigen\u2010injected knee. Pannus developed, extending over the articular surfaces, and extensive erosion of cartilage and subchondral bone occurred. Multinucleated giant cells, together with fibrin\u2010like material, were observed at sites of active bone erosion and debris, and large numbers of neutrophils were seen in the joint space. These pathologic features represent a new arthritis model in which IL\u20101 profoundly augments a weak inflammatory response and induces acute erosive joint destruction, supporting the hypothesis that IL\u20101 is an important cytokine in the pathogenesis of arthritis.<\/jats:p>","DOI":"10.1002\/art.1780330215","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:03:53Z","timestamp":1171494233000},"page":"253-260","source":"Crossref","is-referenced-by-count":65,"title":["Induction of an acute erosive monarticular arthritis in mice by interleukin\u20101 and methylated bovine serum albumin"],"prefix":"10.1002","volume":"33","author":[{"given":"Nigel D.","family":"Staite","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen A.","family":"Richard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle 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