{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:47:02Z","timestamp":1778802422582,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T00:00:00Z","timestamp":1432512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1027657"],"award-info":[{"award-number":["1027657"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["569938"],"award-info":[{"award-number":["569938"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                      is a sexually transmitted obligate intracellular pathogen that causes inflammatory reactive arthritis, spondylitis, psoriasiform dermatitis, and conjunctivitis in some individuals after genital infection. The immunologic basis for this inflammatory response in susceptible hosts is poorly understood. As ZAP\u201070\n                      <jats:sup>W163C<\/jats:sup>\n                      \u2013mutant BALB\/c (SKG) mice are susceptible to spondylo\u2010arthritis after systemic exposure to microbial \u03b2\u2010glucan, we undertook the present study to compare responses to infection with\n                      <jats:italic>Chlamydia muridarum<\/jats:italic>\n                      in SKG mice and BALB\/c mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      After genital or respiratory infection with\n                      <jats:italic>C muridarum<\/jats:italic>\n                      , conjunctivitis and arthritis were assessed clinically, and eye, skin, and joint specimens were analyzed histologically. Chlamydial major outer membrane protein antigen\u2013specific responses were assessed in splenocytes. Treg cells were depleted from FoxP3\u2010DTR BALB\/c or SKG mice, and chlamydial DNA was quantified by polymerase chain reaction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five weeks after vaginal infection with live\n                      <jats:italic>C muridarum<\/jats:italic>\n                      , arthritis, spondylitis, and psoriasiform dermatitis developed in female SKG mice, but not in BALB\/c mice. Inflammatory bowel disease did not occur in mice of either strain. The severity of inflammatory disease was correlated with\n                      <jats:italic>C muridarum<\/jats:italic>\n                      inoculum size and vaginal burden postinoculation. Treatment with combination antibiotics starting 1 day postinoculation prevented disease. Chlamydial antigen was present in macrophages and spread from the infection site to lymphoid organs and peripheral tissue. In response to chlamydial antigen, production of interferon\u2010\u03b3 and interleukin\u201017 was impaired in T cells from SKG mice but tumor necrosis factor (TNF) responses were exaggerated, compared to findings in T cells from BALB\/c mice. Unlike previous observations in arthritis triggered by \u03b2\u2010glucan, no autoantibodies developed. Accelerated disease triggered by depletion of Treg cells was TNF dependent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In the susceptible SKG strain,\n                      <jats:italic>Chlamydia<\/jats:italic>\n                      \u2010induced reactive arthritis develops as a result of deficient intracellular pathogen control, with antigen\u2010specific TNF production upon dissemination of antigen, and TNF\u2010dependent inflammatory disease.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.39041","type":"journal-article","created":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T14:38:58Z","timestamp":1422283138000},"page":"1535-1547","source":"Crossref","is-referenced-by-count":40,"title":["High\n                    <i>Chlamydia<\/i>\n                    Burden Promotes Tumor Necrosis Factor\u2013Dependent Reactive Arthritis in SKG Mice"],"prefix":"10.1002","volume":"67","author":[{"given":"Athan C.","family":"Baillet","sequence":"first","affiliation":[{"name":"University of Queensland Diamantina Institute, Translational Research Institute and Princess Alexandra Hospital Brisbane Queensland Australia"}]},{"given":"Linda M.","family":"Rehaume","sequence":"additional","affiliation":[{"name":"University of Queensland Diamantina Institute, Translational Research Institute and Princess Alexandra Hospital Brisbane Queensland Australia"}]},{"given":"Helen","family":"Benham","sequence":"additional","affiliation":[{"name":"University of Queensland Diamantina Institute, Translational Research Institute and Princess Alexandra Hospital Brisbane Queensland Australia"}]},{"given":"Connor P.","family":"O'Meara","sequence":"additional","affiliation":[{"name":"Queensland University of Technology Brisbane Queensland Australia"}]},{"given":"Charles W.","family":"Armitage","sequence":"additional","affiliation":[{"name":"Queensland University of Technology Brisbane Queensland Australia"}]},{"given":"Roland","family":"Ruscher","sequence":"additional","affiliation":[{"name":"University of Queensland Diamantina Institute, Translational Research Institute and Princess Alexandra Hospital Brisbane Queensland Australia"}]},{"given":"Geraldine","family":"Brizard","sequence":"additional","affiliation":[{"name":"Lions Eye Institute Nedlands West Australia Australia"}]},{"given":"Marina C. G.","family":"Harvie","sequence":"additional","affiliation":[{"name":"Queensland University of Technology Brisbane Queensland Australia"}]},{"given":"Jared","family":"Velasco","sequence":"additional","affiliation":[{"name":"University of Queensland Diamantina Institute, Translational Research Institute and Princess Alexandra Hospital Brisbane Queensland Australia"}]},{"given":"Phillip M.","family":"Hansbro","sequence":"additional","affiliation":[{"name":"Hunter Medical Research Institute and University of Newcastle Newcastle New South Wales Australia"}]},{"given":"John V.","family":"Forrester","sequence":"additional","affiliation":[{"name":"Lions Eye Institute, Nedlands, West Australia, Australia, and University of Aberdeen Medical School Aberdeen Scotland"}]},{"given":"Mariapia A.","family":"Degli\u2010Esposti","sequence":"additional","affiliation":[{"name":"Lions Eye Institute Nedlands West Australia Australia, and University of West Australia Crawley West Australia Australia"}]},{"given":"Kenneth W.","family":"Beagley","sequence":"additional","affiliation":[{"name":"Queensland University of Technology Brisbane Queensland Australia"}]},{"given":"Ranjeny","family":"Thomas","sequence":"additional","affiliation":[{"name":"University of Queensland Diamantina Institute, Translational Research Institute and Princess Alexandra Hospital Brisbane Queensland Australia"}]}],"member":"311","published-online":{"date-parts":[[2015,5,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390715"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30272"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg163"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039460"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780381008"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062259"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061962"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2009.04.002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.02.011"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0804308"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.223.215"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2009.3"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.7.4210-4216.2004"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/515280"},{"key":"e_1_2_6_16_1","first-page":"163","article-title":"Induction of arthritis in C57B1\/6 mice by chlamydial antigen: effect of prior immunization or infection","volume":"130","author":"Hough AJ","year":"1988","journal-title":"Am J Pathol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1162"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803075"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200310001-00003"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34423"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.11.7178-7181.2001"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.4.1282-1286.1998"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103217200"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041758"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02119"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.6.2145-2152.1997"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.158.7.3344"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00984-10"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.6187"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3182648740"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039214"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020846"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018833"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000848"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110377"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2773"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2005.12.004"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27394"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38773"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.3.260"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199906)42:6<1281::AID-ANR27>3.0.CO;2-8"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24431"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(01)01504-0"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.042226"},{"key":"e_1_2_6_45_1","first-page":"501","article-title":"Molecular mimicry in Reiter's syndrome: cytotoxicity and ELISA studies of HLA\u2010microbial relationships","volume":"58","author":"Inman RD","year":"1986","journal-title":"Immunology"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21643"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2011.01.018"},{"key":"e_1_2_6_48_1","first-page":"346","article-title":"Acute arthritis in Zimbabwean patients: possible relationship to human immunodeficiency virus infection","volume":"16","author":"Davis P","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121192"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.12.3288-3297.2000"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.11.3001-3008.2001"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39041","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.39041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:28:07Z","timestamp":1759922887000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.39041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,25]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1002\/art.39041"],"URL":"https:\/\/doi.org\/10.1002\/art.39041","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725526868.793507141","asserted-by":"object"}]},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,25]]}}}