{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:40:09Z","timestamp":1778319609084,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T00:00:00Z","timestamp":1297296000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research Pt B"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND:<\/jats:bold> Prenatal exposure to the persistent environmental pollutant and model <jats:italic>Ah<\/jats:italic> receptor agonist, 2,3,7,8\u2010tetrachlorodibenzo\u2010p\u2010dioxin (TCDD), has been shown to permanently suppress postnatal cell\u2010mediated immunity. More recently, skewing of select adult T and B cell responses toward enhanced inflammation has also been described in C57BL\/6 mice after prenatal TCDD. This raises questions about adverse postnatal immune consequences of prenatal TCDD in animals genetically predisposed to inappropriate inflammatory responses. <jats:bold>METHODS:<\/jats:bold> Lupus\u2010prone SNF<jats:sub>1<\/jats:sub> mice were exposed to 0, 40, or 80\u2009\u00b5g\/kg TCDD on gestation day (gd) 12 and examined at 36 weeks\u2010of\u2010age for immunomodulatory effects that correlated with worsened lupus pathology. <jats:bold>RESULTS:<\/jats:bold> Bone marrow pro\u2010 and large pre\u2010B cells were decreased by prenatal TCDD, in both adult male and female mice, as were pre\u2010 and immature B cells. Splenic CD23<jats:sup>\u2212<\/jats:sup>CD1<jats:sup>hi<\/jats:sup> and CD19<jats:sup>+<\/jats:sup>CD5<jats:sup>+<\/jats:sup> B cells were increased in males, as were B220<jats:sup>hi<\/jats:sup> B cells in females, further suggesting persistent disruption of B cell lymphopoiesis by prenatal TCDD. Female mice displayed decreased IL\u201010 production by ConA\u2010activated splenocytes, while males underproduced IL\u20104. Autoreactive CD4<jats:sup>+<\/jats:sup>V\u03b217a<jats:sup>+<\/jats:sup> spleen T cells were increased in both sexes by 80\u2009\u00b5g\/kg TCDD. Male mice but not females showed increased anti\u2010ds DNA and cardiolipin autoantibody levels. <jats:bold>CONCLUSIONS:<\/jats:bold> Prenatal TCDD augmented the hallmark indicators of SLE progression in the lupus\u2010prone SNF<jats:sub>1<\/jats:sub> mice, including renal immune complex deposition, glomerulonephritis, and mesangial proliferation. Prenatal TCDD therefore caused persistent modulation of the postnatal immune response, and exacerbated inflammatory disease, in lupus\u2010like autoimmune SNF<jats:sub>1<\/jats:sub> mice. <jats:italic>Birth Defects Res (Part B)<\/jats:italic> 92:82\u201394, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdrb.20285","type":"journal-article","created":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T23:50:57Z","timestamp":1297381857000},"page":"82-94","source":"Crossref","is-referenced-by-count":14,"title":["Prenatal TCDD causes persistent modulation of the postnatal immune response, and exacerbates inflammatory disease, in 36\u2010week\u2010old lupus\u2010like autoimmune SNF<sub>1<\/sub> mice"],"prefix":"10.1002","volume":"92","author":[{"given":"Amjad","family":"Mustafa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Holladay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Witonsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Manari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheryl","family":"Countermarsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Karpuzoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Gogal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.10.1453"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(02)00025-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/026520300283351"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-437X(95)80028-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(98)80028-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-004-0624-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1001971"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.10.007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.4049\/jimmunol.131.5.2232","article-title":"Genetic analysis of the inheritance of B cell hyperactivity in relation to the development of autoantibodies and glomerulonephritis in NZB \u00d7 SWR crosses","volume":"131","author":"Eastcott JW","year":"1983","journal-title":"J Immunol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1988.186"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(99)00024-4"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(97)00099-1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.1886"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2010.08.001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.158.3.1175"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfh094"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.1.75"},{"key":"e_1_2_6_19_1","first-page":"1495","article-title":"Multiple autoantibodies form the glomerular immune deposits in patients with systemic lupus erythematosus","volume":"30","author":"Mannik M","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1931"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.154.3.1470"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930500050277"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2008.04.015"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfp177"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20603"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.03944.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri955"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220314"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80029-1"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/10.11.1673"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.67.89"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/58.1.88"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287390500246985"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2003.08.012"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031519"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.2002.9396"},{"key":"e_1_2_6_37_1","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.4049\/jimmunol.158.5.2165","article-title":"Activation of the aryl hydrocarbon receptor\/transcription factor and bone marrow stromal cell\u2010dependent preB cell apoptosis","volume":"158","author":"Yamaguchi K","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfh013"}],"container-title":["Birth Defects Research Part B: Developmental and Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdrb.20285","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdrb.20285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T13:13:18Z","timestamp":1696943598000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdrb.20285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1002\/bdrb.20285"],"URL":"https:\/\/doi.org\/10.1002\/bdrb.20285","archive":["Portico"],"relation":{},"ISSN":["1542-9733","1542-9741"],"issn-type":[{"value":"1542-9733","type":"print"},{"value":"1542-9741","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}