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We propose that, in addition to its role as an angiogenic factor, vascular endothelial growth factor (VEGF) can act as a survival factor for tumour cells protecting them from apoptosis. Thus anti\u2010angiogenics, in particular those directed against VEGF, have multiple anti\u2010tumour effects. We suggest that anti\u2010VEGF strategies prevent vessel growth and block a tumour cell survival factor, VEGF, rendering tumour cells more sensitive to chemotherapy and radiotherapy. In addition, as chemotherapy and radiotherapy have been shown to increase VEGF expression, anti\u2010VEGF strategies may overcome therapy\u2010 induced tumour cell resistance. 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