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At this point, the cellular environment is assessed; only if conditions are appropriate do cells traverse START, thus becoming committed to initiate DNA replication and complete the remainder of the cell cycle. The <jats:italic>cdc<\/jats:italic>2<jats:sup>+<\/jats:sup> \/ <jats:italic>CDC<\/jats:italic>28<jats:sup>+<\/jats:sup> gene, encoding the protein kinase p34, is a key element in this complex control. The identification of structural and functional homologues of p34 suggests that it has a role in the control of DNA replication in all eukaryotes. The <jats:italic>WHI1<\/jats:italic><jats:sup>+<\/jats:sup>, <jats:italic>CLN1<\/jats:italic><jats:sup>+<\/jats:sup> and <jats:italic>CLN2<\/jats:italic><jats:sup>+<\/jats:sup> gene products, identified in <jats:italic>S. cerevisiae<\/jats:italic>, are positive regulators that function at START and may interact with p34. Determining how passing the START control point leads to the initiation of DNA replication is a major outstanding challenge in cell cycle studies.<\/jats:p>","DOI":"10.1002\/bies.950121002","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T11:03:09Z","timestamp":1109329389000},"page":"457-463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Yeast as a model system for understanding the control of DNA replication in eukaryotes"],"prefix":"10.1002","volume":"12","author":[{"given":"Rachel","family":"Bartlett","sequence":"first","affiliation":[]},{"given":"Paul","family":"Nurse","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"97","volume-title":"The Molecular Biology of the Yeast Saccharomyces, Life Cycle and Inheritance","author":"Pringle J. 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