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We review the growth cone as a transduction device, converting extracellular signals into mechanical forces. A variety of soluble, extracellular matrix and membrane bound molecules control growth cone behavior. In addition, GAP\u201043 is discussed as a possible component of the Intraneuronal gene program which modulates growth cone activity. The GTP\u2010binding protein, G<jats:sub>o<\/jats:sub>, is a major growth cone membrane protein that may transduce signals not only from outside the cell, but from within as well. 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