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The cytoplasmic domains of these microfilament\u2010membrane associations at the adherens junction sites, also Iocalize a variety of regulatory molecules involved in signal transduction and gene regulation. The stimulation of cells with soluble polypeptide factors leads to rapid changes in cell shape and microfilament component organization. In addition, this stimulation also activates the phosphoinositide signaling pathway. Recently, a linkage between actin\u2010binding proteins and the phosphoinositide signaling pathway, was discovered. 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