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Surprisingly, HNF1 is not restricted to hepatocytes but is expressed in epithelial cells of several endoderm derived organs and in mesoderm derived kidney tubules. Hence, HNF1 alone can not account for the differentiated state of the hepatic cells. In fact, several other liver\u2010enriched transcription factors have been cloned. The hepatic phenotype could result from the combinatorial. expression of these regulators. Possible involvement of these trans\u2010acting factors in liver organogenesis and hepatic differentiation is discussed.<\/jats:p>","DOI":"10.1002\/bies.950140902","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T10:23:33Z","timestamp":1109327013000},"page":"579-587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":157,"title":["HNF1, a homeoprotein member of the hepatic transcription regulatory network"],"prefix":"10.1002","volume":"14","author":[{"given":"Fran\u00e7lois","family":"Tronche","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Yaniv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"427","article-title":"An experimental analysis of liver development","volume":"53","author":"Le Douarin N.","year":"1975","journal-title":"Med. 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