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Collectively, these control mechanisms have become known as checkpoints. Analysis of checkpoints is facilitated by the fact that dependency relationships within the cell cycle, such as the dependency of mitosis on the completion of DNA synthesis, and the DNA damage checkpoint can be separated genetically. In fission yeast, <jats:italic>Schizosaccharomyces pombe<\/jats:italic>, the dependency of mitosis on prior completion of DNA synthesis is mediated through tyrosine\u201015 phosphorylation of the ubiquitous mitotic regulator p34<jats:sup>cdc2<\/jats:sup>. In contrast, the arrest of mitosis caused by DNA damage acts through a separate mechanism that appears to be independent of tyrosine\u201015 phosphorylation. Despite these distinct interactions with the mitotic machinery, the majority of fission yeast mutants that are deficient in mitotic arrest after DNA damage are also unable to respond to inhibition of DNA synthesis. In this essay we survey the current knowledge concerning feedback controls and checkpoints within fission yeast and relate this to information derived from other systems.<\/jats:p>","DOI":"10.1002\/bies.950151202","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T09:18:01Z","timestamp":1109323081000},"page":"775-782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Feedback controls and G2 checkpoints: Fission yeast as a model system"],"prefix":"10.1002","volume":"15","author":[{"given":"Katherine S.","family":"Sheldrick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antony M.","family":"Carr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90542-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2683079"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/359599a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90669-6"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(68)86567-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.10.12.6554"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05179.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05178.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/344503a0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90458-2"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90266-2"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90546-5"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90177-E"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"4933","DOI":"10.1002\/j.1460-2075.1992.tb05600.x","article-title":"Pyp3 PTPase acts as a mitotic inducer in fission yeast","volume":"13","author":"Millar J. B. A.","year":"1992","journal-title":"EMBO J."},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/342039a0"},{"key":"e_1_2_1_17_2","first-page":"125","volume-title":"Cell Cycle Controls","author":"Mitchison J. M.","year":"1974"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/363368a0"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","unstructured":"Al\u2010Khodairy F. Fotou E. Sheldrick K. S. Griffiths D. J. F. Lehmann A. R.andCarr A. M.(1993).Identification and characterisation of new elements involved in checkpoints and feedback controls in fission yeast. 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