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In the canonical phosphoinositide turnover pathway, activation of phosphatidylinositol\u2010specific phospholipase C results in the hydrolysis of phosphatidylinositol 4,5\u2010bisphospate and the generation of two second messengers, inositol 1,4,5\u2010trisphosphate and diacylglycerol. The 3\u2010phosphoinositide pathway involves protein\u2010tyrosine kinase\u2010mediated recruitment and activation of phosphatidylinositol 3\u2010kinase, resulting in the production of phosphatidylinositol 3,4\u2010bisphosphate and phosphatidylinositol 3,4,5\u2010trisphosphate. The 3\u2010phosphoinositides are not substrates of any known phospholipase C, are not components of the canonical phosphoinositide turnover pathway, and may themselves act as intracellular mediators. The 3\u2010phosphoinositide pathway has been implicated in growth factor\u2010dependent mitogenesis, membrane ruffling and glucose uptake. Furthermore the homology of the yeast vps34 with the mammalian phosphatidylinositol 3\u2010kinase has suggested a role for this pathway in vesicular trafficking.<\/jats:p><jats:p>In this review the different mechanisms employed by protein\u2010tyrosine kinases to activate phosphatidylinositol 3\u2010kinase, and its involvement in the signaling cascade initiated by tyrosine phosphorylation, are examined.<\/jats:p>","DOI":"10.1002\/bies.950160810","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T09:58:55Z","timestamp":1109325535000},"page":"565-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":471,"title":["Phosphatidylinositol 3\u2010kinase"],"prefix":"10.1002","volume":"16","author":[{"given":"Rosana","family":"Kapeller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis C.","family":"Cantley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90801-K"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90639-G"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/332644a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90232-F"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(93)90072-W"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(94)90051-5"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00503a001"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-13-4-692"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"19704","DOI":"10.1016\/S0021-9258(17)45429-9","article-title":"Purification and characterization of phosphoinositide 3\u2010kinase from rat liver","volume":"265","author":"Carpenter C. 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