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The glycosyl phosphatidylinositol anchor is a signal for apical targeting. Signals in the cytoplasmic domain containing a \u03b2\u2010turn determine basolateral targeting and retrieval, and are related to other sorting signals. Transcytosed proteins, such as the polymeric immunoglobulin receptor (plgR), are endocytosed from the basolateral surface and then accumulate in a tubular compartment concentrated underneath the apical surface. This compartment, tentatively termed the apical recycling compartment, may be a central sorting station, as it apparently receives material from both surfaces and sorts them for delivery to the correct surface. Delivery to the apical surface from both the TGN and the apical recycling compartment appears to be regulated by protein kinases A and C, and endocytosis from the apical surface is also regulated by kinases. Transcytosis of the plgR is additionally regulated by phosphorylation of the plgR and by ligand binding to the plgR. Regulation of traffic in polarized epithelial cells plays a central role in cellular homeostasis, response to external signals and differentiation.<\/jats:p>","DOI":"10.1002\/bies.950170208","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T08:36:09Z","timestamp":1109320569000},"page":"129-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["Regulation of protein traffic in polarized epithelial cells"],"prefix":"10.1002","volume":"17","author":[{"given":"Keith E.","family":"Mostov","sequence":"first","affiliation":[]},{"given":"Michael H.","family":"Cardone","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.116.3.577"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.08.110192.002143"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1658934"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00417a001"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8924(94)90114-7"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06233.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06437.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90139-P"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.000431"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90592-1"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90887-1"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.126.4.991"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.123.5.1149"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"15732","DOI":"10.1016\/S0021-9258(17)40742-3","article-title":"The basolateral targeting signal of the cytoplasmic domain of VSV G protein resembles a variety of intracellular targeting motifs related by primary sequence but having diverse targeting activities","volume":"269","author":"Thomas D. 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