{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T12:48:39Z","timestamp":1780663719893,"version":"3.54.1"},"reference-count":66,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,5]],"date-time":"2005-02-05T00:00:00Z","timestamp":1107561600000},"content-version":"vor","delay-in-days":3629,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gene targeting has allowed the dissection of complex biological processes at the genetic level. Our understanding of the nuances of skeletal muscle development has been greatly increased by the analysis of mice carrying targeted null mutations in the <jats:italic>Myf<\/jats:italic>\u20105, <jats:italic>MyoD<\/jats:italic> and <jats:italic>myogenin<\/jats:italic> genes, encoding members of the myogenic regulatory factor (MRF) family. These experiments have elucidated the hierarchical relationships existing between the MRFs, and established that functional redundancy is a feature of the MRF regulatory network. Either MyoD or Myf\u20105 is sufficient for the formation or survival of skeletal myoblasts. Myogenin acts later in development and plays an essential <jats:italic>in vivo<\/jats:italic> role in the terminal differentiation of myotubes.<\/jats:p>","DOI":"10.1002\/bies.950170306","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T08:41:58Z","timestamp":1109320918000},"page":"203-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":379,"title":["The MyoD family of transcription factors and skeletal myogenesis"],"prefix":"10.1002","volume":"17","author":[{"given":"Michael A.","family":"Rudnicki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Jaenisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1846704"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-437X(93)90033-L"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90610-3"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00014-2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.1.1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90434-0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.3.677"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2105528"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1128\/jvi.65.11.6084-6093.1991","article-title":"Helix\u2010loop\u2010helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers","volume":"65","author":"Corneliussen B.","year":"1991","journal-title":"J. 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