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These findings explain a particular pattern of DNA degradation during inhibition of chromosomal replication, the role of recombination in the viability of mutants with displaced replication origin, and hyper\u2010recombination observed in the Terminus of the <jats:italic>E. coli<\/jats:italic> chromosome in <jats:italic>rnh<\/jats:italic> mutants. Breakage and repair of inhibited replication forks could be the reason for the recombination\u2010dependence of inducible stable DNA replication. A mechanism by which RecABCD\u2010dependent recombination between very short inverted repeats may help <jats:italic>E. coli<\/jats:italic> to invert an operon, transcribed in the direction opposite to that of DNA replication, is discussed.<\/jats:p>","DOI":"10.1002\/bies.950170810","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T09:10:24Z","timestamp":1109322624000},"page":"733-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Instability of inhibited replication forks in <i>E. coli<\/i>"],"prefix":"10.1002","volume":"17","author":[{"given":"Andrei","family":"Kuzminov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1527","volume-title":"Escherichia coli and Salmonella typhimurium","author":"Bremer H.","year":"1987"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1995.tb02403.x"},{"key":"e_1_2_1_4_2","first-page":"231","volume-title":"Genetic Recombination","author":"Taylor A. 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