{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T09:49:08Z","timestamp":1773740948335,"version":"3.50.1"},"reference-count":71,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,2,5]],"date-time":"2005-02-05T00:00:00Z","timestamp":1107561600000},"content-version":"vor","delay-in-days":3445,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Homeotic genes are subject to transcriptional silencing, which prevents their expression in inappropriate body regions. Here, we shall focus on <jats:italic>Drosophila<\/jats:italic>, as little is known about this process in other organisms. Evidence is accumulating that silencing of <jats:italic>Drosophila<\/jats:italic> homeotic genes is conferred by two types of <jats:italic>cis<\/jats:italic>\u2010regulatory sequences: initiation (SIL\u2010I) and maintenance (SIL\u2010M) elements. The former contain target sites for transient repressors with a highly localised distribution in the early embryo and the latter for constitutive repressors that are likely to be present in all cells. We discuss how SIL\u2010I elements may cooperate with SIL\u2010M elements to promote formation of a silencing complex. We propose that this complex consists of specific non\u2010histone proteins, the so\u2010called <jats:italic>Polycomb<\/jats:italic> group proteins, and that it is anchored at SIL\u2010M elements and at the promoter.<\/jats:p>","DOI":"10.1002\/bies.950170907","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T09:12:51Z","timestamp":1109322771000},"page":"775-784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Transcriptional silencing of homeotic genes in <i>drosophila<\/i>"],"prefix":"10.1002","volume":"17","author":[{"given":"Mariann","family":"Bienz","sequence":"first","affiliation":[]},{"given":"J\u00fcrg","family":"M\u00fcller","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/276565a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/genetics\/94.1.115","article-title":"Cytogenetic analysis of chromosome 3 in Drosophila melanogaster","volume":"94","author":"Kaufman T. 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