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More recently, powerful genetic analysis in yeast has proved useful in unraveling aspects of translation inherently more difficult to address by strictly biochemical approaches. One area in particular is the functional analysis of multi\u2010subunit protein factors, termed eukaryotic initiation factors (eIFs), that play an essential role in translation initiation. eIF\u20103, the most structurally complex of the eIFs, has until recently eluded this approach. The identification of the yeast <jats:italic>GCD10<\/jats:italic> gene as the structural gene for the \u03b6 subunit of yeast eIF\u20103<jats:sup>(1)<\/jats:sup> and the analysis of mutant phenotypes has opened the door to the genetic dissection of the eIF\u20103 protein complex.<\/jats:p>","DOI":"10.1002\/bies.950171103","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T10:04:15Z","timestamp":1109325855000},"page":"915-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Protein synthesis in eukaryotic organisms: New insights into the function of translation initiation factor EIF\u20103"],"prefix":"10.1002","volume":"17","author":[{"given":"Ernest M.","family":"Hannig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.14.1781"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.60.070191.003441"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.56.2.291-315.1992"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2350625"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1992.tb00861.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.08.110192.001213"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3051379"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.8.2784"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(88)80006-0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb07218.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.13.1.506"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)30005-5"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(94)90089-2"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1874-6047(08)60263-2"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1016\/S0021-9258(18)53649-8","article-title":"Regulation of eukaryotic protein synthesis by initiation factors","volume":"268","author":"Rhoads R. 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