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Due to the specificity of Watson\u2010Crick base\u2010pair hybridization, antisense oligodeoxynucleotides have been used extensively in attempts to inhibit gene expression in both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> models. Analogues modified from normal phosphodiester oligodeoxynucleotides have entered clinical trials against diseases including AIDS and cancer. Although the precise mechanism of action of these drugs has not been clarified, these oligodeoxynucleotides offer considerable promise as novel molecular therapeutics. 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