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With the exception of the inactive X chromosome in female cells, where the bulk of histone H4 is under\u2010acetylated, H4 hyperacetylation is non\u2010uniformly distributed along the chromosomes and clustered in cytologically resolvable chromatin domains that correspond, in general, with the R\u2010bands of conventional staining. The strongest immunolabelling is often found in T\u2010bands, the subset of intense R\u2010bands having the highest GC content. The majority of mapped genes also occurs in R\u2010band regions, with the highest gene density in T\u2010bands. These observations are consistent with a model in which hyperacetylation of histone H4 marks the position of potentially active gene sequences on metaphase chromosomes. Since acetylation is maintained during mitosis, progeny cells receive an imprint of the histone H4 acetylation pattern that was present on the parental chromosomes before cell division. Histone acetylation could provide a mechanism for propagating cell memory, defined as the maintenance of committed states of gene expression through cell lineages.<\/jats:p>","DOI":"10.1002\/bies.950190111","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T10:55:09Z","timestamp":1109328909000},"page":"67-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Histone acetylation: A possible mechanism for the inheritance of cell memory at mitosis"],"prefix":"10.1002","volume":"19","author":[{"given":"Peter","family":"Jeppesen","sequence":"first","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/311532a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.83.2.403"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/355219a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/10409238609083735"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.51.5.786"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2650023"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.99.1.13"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.108.5.1577"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90339-G"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90526-I"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb02956.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/20.5.1017"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.7.4.592"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5260.408"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81063-6"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.30.17923"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90417-B"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.1.96"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00346011"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90419-Q"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02281863"},{"key":"e_1_2_1_23_2","first-page":"497","article-title":"The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation","volume":"55","author":"Migeon B. 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