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This is due in part to the varied reports of its localization on mitotic chromosomes, which has been described at different times as uniformly distributed, axial on the chromosome arms and predominantly centromeric. These disparate results are probably due to several factors, including use of different preparation and fixation techniques, species differences and changes in distribution during the cell cycle. Recently, several papers have re\u2010investigated the distribution of topo II on chromosomes as a function of cell cycle and species<jats:sup>(1\u20133)<\/jats:sup>. The new studies suggest that Topo II has a dynamic pattern of distribution on the chromosomes, in general becoming axial as chromosomes condense during prophase and then concentrating at centromeres during metaphase. These experiments suggest a novel role for topo II in centromere structure and function.<\/jats:p>","DOI":"10.1002\/bies.950190203","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T11:01:42Z","timestamp":1109329302000},"page":"97-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Untangling the role of DNA topoisomerase II in mitotic chromosome structure and function"],"prefix":"10.1002","volume":"19","author":[{"given":"Peter E.","family":"Warburton","sequence":"first","affiliation":[]},{"given":"William C.","family":"Earnshaw","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.134.5.1097"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02254938"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02265053"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90433-2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(81)90173-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04315.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.9.2616"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1984.tb02040.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(85)80028-3"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90518-6"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.117.5.921"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90215-K"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1242\/jcs.104.4.1175","article-title":"Consequences of topoisomerase II inhibition in early embryogenesis of Drosophila revealed by in vivo confocal laser scanning microscopy","volume":"104","author":"Buchenau P.","year":"1993","journal-title":"J. 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