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In rat hepatocytes treated with adriamycin incubation with exogenous Coenzyme Q<jats:sub>10<\/jats:sub> counteracted the drug\u2010induced increase of hydrogen peroxide and the fall of the mitochondrial potential, thus demonstrating the quinone antioxidant effect.<\/jats:p><jats:p>Complex I activity and its rotenone sensitivity decreased in brain cortex non\u2010synaptic mitochondria from old rats; a 5 kb mitochondrial DNA deletion was found only in the old rats. A similar behavior was found in human platelets from old individuals. The postulated energy decline was confirmed by the inhibitor sensitivities of platelet aggregation and lactate production. The lack of the 5 kb deletion in platelets throws doubts on mitochondrial DNA lesions as the only causes of mitochondrial dysfunction in aging.<\/jats:p>","DOI":"10.1002\/biof.5520080305","type":"journal-article","created":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T01:14:41Z","timestamp":1229649281000},"page":"195-204","source":"Crossref","is-referenced-by-count":57,"title":["Oxidative stress, antioxidant defences and aging"],"prefix":"10.1002","volume":"8","author":[{"given":"Giorgio","family":"Lenaz","sequence":"first","affiliation":[]},{"given":"Marika","family":"Cavazzoni","sequence":"additional","affiliation":[]},{"given":"Maria Luisa","family":"Genova","sequence":"additional","affiliation":[]},{"given":"Marilena","family":"D'Aurelio","sequence":"additional","affiliation":[]},{"given":"Milena Merlo","family":"Pich","sequence":"additional","affiliation":[]},{"given":"Francesco","family":"Pallotti","sequence":"additional","affiliation":[]},{"given":"Gabriella","family":"Formiggini","sequence":"additional","affiliation":[]},{"given":"Mario","family":"Marchetti","sequence":"additional","affiliation":[]},{"given":"Giovanna Parenti","family":"Castelli","sequence":"additional","affiliation":[]},{"given":"Carla","family":"Bovina","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2008,12,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/BF00762735","article-title":"Recent progress on regulation of the mitochondrial permeability transition pore, a cyclosporin sensitive pore in the inner mitochondrial membrane","volume":"26","author":"Bernardi P.","year":"1994","journal-title":"J. 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