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On the basis of this combined stoichiometric growth model, we explored the topological features of the <jats:italic>B. subtilis<\/jats:italic> metabolic reaction network that was assembled from a large amount of literature. More specifically, we simulated maximum theoretical yields of biomass and riboflavin, including the associated flux regimes. Based on the developed model, the importance of experimental data on building block requirements for maximum yield and flux calculations were investigated. These analyses clearly show that verification of macromolecular composition data is important for optimum flux calculations.  \u00a9 2001 John Wiley &amp; Sons, Inc. 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