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Controls had sham JIB. Colorectal adaptation was studied 30 weeks postoperatively in rats given injections of vehicle alone. JIB caused 17\u201333 per cent increments in colonic length, weight and crypt depth; crypt cell production rate was more than doubled (P &amp;lt; 0.01). Despite lowering body weight by 27 per cent, JIB increased the median number of colorectal tumours per rat from 3 to 8 (P &amp;lt; 0.01). The findings suggest that evidence of hyperplasia and dysplasia should be sought in patients receiving subtotal jejunoileal bypass for obesity.<\/jats:p>","DOI":"10.1002\/bjs.1800710216","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T00:25:57Z","timestamp":1172881557000},"page":"123-126","source":"Crossref","is-referenced-by-count":36,"title":["Adaptation to jejunoileal bypass promotes experimental colorectal carcinogenesis"],"prefix":"10.1093","volume":"71","author":[{"given":"J B","family":"Bristol","sequence":"first","affiliation":[{"name":"University Department of Surgery, Bristol Royal Infirmary , Bristol BS2 8HW,","place":["UK"]}]},{"given":"M","family":"Wells","sequence":"additional","affiliation":[{"name":"University Department of Surgery, Bristol Royal Infirmary , Bristol BS2 8HW,","place":["UK"]}]},{"given":"R C N","family":"Williamson","sequence":"additional","affiliation":[{"name":"University Department of Surgery, Bristol Royal Infirmary , Bristol BS2 8HW,","place":["UK"]}]}],"member":"286","published-online":{"date-parts":[[1984,2,1]]},"reference":[{"key":"2024092716194145200_bib1","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1056\/NEJM197806222982505","article-title":"Intestinal adaptation","volume":"298","author":"Williamson","year":"1978","journal-title":"N Engl J Med"},{"key":"2024092716194145200_bib2","first-page":"21","article-title":"Intestinal adaptation: factors that influence morphology","volume":"17","author":"Williamson","year":"1982","journal-title":"Scand J Gastroenterol"},{"key":"2024092716194145200_bib3","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0016-5085(71)80036-7","article-title":"Epithelial cell kinetics in the small intestine of the rat 60 days after resection of 70 per cent of the ileum and jejunum","volume":"60","author":"Hanson","year":"1971","journal-title":"Gastroenterology"},{"key":"2024092716194145200_bib4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0016-5085(71)80008-2","article-title":"Studies of small bowel adaptation after intestinal resection in the rat","volume":"60","author":"Weser","year":"1971","journal-title":"Gastroenterology"},{"key":"2024092716194145200_bib5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/bjs.1800690106","article-title":"The effect of altered luminal nutrition on cellular proliferation and plasma concentrations of enteroglucagon and gastrin after small bowel resection in the rat","volume":"69","author":"Sagor","year":"1982","journal-title":"Br J Surg"},{"key":"2024092716194145200_bib6","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/S0016-5085(77)80156-X","article-title":"Compensation by the residual intestine after intestinal resection in the rat: I. 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