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Herein, we report a new strategy for the rapid, sustainable synthesis of HAP hierarchically nanostructured porous hollow microspheres by using creatine phosphate disodium salt as an organic phosphorus source in aqueous solution through a microwave\u2010assisted hydrothermal method. The as\u2010obtained products are characterized by powder X\u2010ray diffraction (XRD), Fourier\u2010transform IR (FTIR) spectroscopy, SEM, TEM, Brunauer\u2013Emmett\u2013Teller (BET) nitrogen sorptometry, dynamic light scattering (DLS), and thermogravimetric analysis (TGA). SEM and TEM micrographs show that HAP hierarchically nanostructured porous hollow microspheres consist of HAP nanosheets or nanorods as the building blocks and DLS measurements show that the diameters of HAP hollow microspheres are within the range 0.8\u20131.5\u2005\u03bcm. The specific surface area and average pore size of the HAP porous hollow microspheres are 87.3\u2005m<jats:sup>2<\/jats:sup>g<jats:sup>\u22121<\/jats:sup> and 20.6\u2005nm, respectively. The important role of creatine phosphate disodium salt and the influence of the experimental conditions on the products were systematically investigated. This method is facile, rapid, surfactant\u2010free and environmentally friendly. The as\u2010prepared HAP porous hollow microspheres show a relatively high drug\u2010loading capacity and protein\u2010adsorption ability, as well as sustained drug and protein release, by using ibuprofen as a model drug and hemoglobin (Hb) as a model protein, respectively. These experiments indicate that the as\u2010prepared HAP porous hollow microspheres are promising for applications in biomedical fields, such as drug delivery and protein adsorption.<\/jats:p>","DOI":"10.1002\/chem.201203886","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T01:29:21Z","timestamp":1362446961000},"page":"5332-5341","source":"Crossref","is-referenced-by-count":148,"title":["Hydroxyapatite Hierarchically Nanostructured Porous Hollow Microspheres: Rapid, Sustainable Microwave\u2010Hydrothermal Synthesis by Using Creatine Phosphate as an Organic Phosphorus Source and Application in Drug Delivery and Protein Adsorption"],"prefix":"10.1002","volume":"19","author":[{"given":"Chao","family":"Qi","sequence":"first","affiliation":[]},{"given":"Ying\u2010Jie","family":"Zhu","sequence":"additional","affiliation":[]},{"given":"Bing\u2010Qiang","family":"Lu","sequence":"additional","affiliation":[]},{"given":"Xin\u2010Yu","family":"Zhao","sequence":"additional","affiliation":[]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Jin","family":"Wu","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2013,3,4]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10853-006-1467-8"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr8004422"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma2020399"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3757(20020902)114:17<3260::AID-ANGE3260>3.0.CO;2-S"},{"key":"e_1_2_6_4_3","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20020902)41:17<3130::AID-ANIE3130>3.0.CO;2-1"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/b800389k"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1039\/B917441A"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2010.12.005"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2011.03.019"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1557\/JMR.1998.0015"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.08.032"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1556-276X-6-67"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/c0jm01036g"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/cg801353n"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpcs.2008.10.011"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2008.07.028"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1039\/C0CE00574F"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/cg7007304"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200600033"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2011.04.104"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201000463"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2jm35280j"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/22\/30\/305610"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp211648x"},{"key":"e_1_2_6_24_2","first-page":"2009","author":"Ma M. 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