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Tau increases the apparent elongation rate of microtubules in proportion to its molar ratio to tubulin, and we present evidence indicating that this is due to a reduction of microtubule instability rather than to an increase of the on rate of tubulin subunits at the end of growing microtubules. Increasing the molar ratio of tau over tubulin leads also to an increase in the average number of microtubules nucleated percentrosome. This number remains constant with time. This suggests that the number of centrosome\u2010nucleated microtubules at steady state can be determined by factors that are not necessarily irreversibly bound to centrosomes but, rather, affect the dynamic properties of microtubules.<\/jats:p>","DOI":"10.1002\/cm.970150205","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T03:27:16Z","timestamp":1109215636000},"page":"88-98","source":"Crossref","is-referenced-by-count":67,"title":["Effects of brain microtubule\u2010associated proteins on microtubule dynamics and the nucleating activity of centrosomes"],"prefix":"10.1002","volume":"15","author":[{"given":"M. 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