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Cell Biol. 4:43\u201352]. However, no functional role nor distinctive localization has been previously identified for non\u2010filamentous \u201cunconventional\u201d myosins, such as myosin I, during cytokinesis. Using antibodies to adrenal medullary myosin I, we report that myosin I is localized in 3T3 fibroblasts to the mid\u2010equatorial plane during late\u2010cytokinesis, as well as to the polar edges as previously described in ameboid cells [Fukui et al., 1989: <jats:italic>Nature<\/jats:italic> 341:328\u2013331]. Confocal microscopy revealed that myosin I is concentrated at the midbody region in a nearly continuous transverse disk, extending from the cortical region of the furrow through the midbody itself. These findings suggest that, in addition to the accepted role of filamentous myosin II in constriction of the contractile ring, non\u2010filamentous myosin I might contribute to motile events occurring late in cytokinesis. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cm.970290404","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T01:54:11Z","timestamp":1109210051000},"page":"312-320","source":"Crossref","is-referenced-by-count":23,"title":["Myosin I localizes to the midbody region during mammalian cytokinesis"],"prefix":"10.1002","volume":"29","author":[{"given":"Jennifer","family":"Breckler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth","family":"Burnside","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/322754a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/340565a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/360084a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.2.490"},{"key":"e_1_2_1_6_1","first-page":"2489","article-title":"Myosin in retinal pigment epithelial cells","volume":"35","author":"Breckler J.","year":"1994","journal-title":"Invest. 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