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They can be related to the iminoether derivatives, which were recently shown to be the first Pt<jats:sup>II<\/jats:sup> compounds with a <jats:italic>trans<\/jats:italic> configuration endowed with anticancer activity. The chemical and biological properties of platinum amidine complexes, and more generally of platinum imino derivatives, can be rationally modified through suitable synthetic procedures with the aim of improving their cytotoxicity and antitumor activity. 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