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The somata of the majority of cortico\u2010cortical cells lie in the supragranular layers. Those projecting to the opposite cortex are confined to the deeper half of layer III (layer IIIB). Ipsilateral cortico\u2010cortical neurons lie mainly superficial to them in layers IIIA and II, but in the second somatic sensory area (SII) and in area 2 of the first (SI), small numbers are also found in layer V. Corticospinal cells lie in the deeper part of layer V and corticostriatal cells in the superficial part. Corticopontine, corticobulbar and corticorubral cells lie in between. The majority of corticothalamic cells lies in layer VI but a second, smaller population is found in the deep part of layer V.<\/jats:p><jats:p>The cells giving rise to a particular set of efferent connections can be distinguished in terms of size and, with the exception of the corticospinal cells, their size does not vary greatly from area to area. In many cases, the size and laminar specificity indicates that cells sending axons to one site cannot have collateral branches projecting to another.<\/jats:p><jats:p>In most of the fiber systems studied, labeled cells form single or multiple strips, 0.5\u20131 mm wide and oriented mediolaterally across the cortex. The strips appear in all of the subfields of the somatic sensory and motor areas and may form the basis of the clustering of like groups of efferent neurons demonstrable in physiological studies.<\/jats:p>","DOI":"10.1002\/cne.901750403","type":"journal-article","created":{"date-parts":[[2004,12,28]],"date-time":"2004-12-28T19:56:20Z","timestamp":1104263780000},"page":"391-437","source":"Crossref","is-referenced-by-count":393,"title":["Size, laminar and columnar distribution of efferent cells in the sensory\u2010motor cortex of monkeys"],"prefix":"10.1002","volume":"175","author":[{"given":"E. G.","family":"Jones","sequence":"first","affiliation":[]},{"given":"S. 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