{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T15:26:05Z","timestamp":1763479565141},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":9262,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1979,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infusion of 1.8 M mannitol solution into the internal corotid artery of Wistar rats allows horseradish peroxidase (HRP) to cross cerebral vascular endothelium via intercellular pathways. This was made evident by density gradients of HRP observed in consecutive tight junctional compartments following in vivo administration, and by the passage of colloidal lanthanum through junctional membrane appositions of glutaradehyde fixed cerebral endothelium. Three hours after mannitol infusion, small no\u2010capillary vascular segments were still focally permeable to HRP. Twenty\u2010four hours after the osmotic insult, the tracer was absent in the affected hemisphere. Water and electrolyte essays indicated absence of brain edema during the period of observation of blood\u2010brain barrier opening.<\/jats:p>","DOI":"10.1002\/cne.901850307","type":"journal-article","created":{"date-parts":[[2004,12,28]],"date-time":"2004-12-28T19:56:24Z","timestamp":1104263784000},"page":"569-578","source":"Crossref","is-referenced-by-count":75,"title":["Opening of tight junctions in cerebral endothelium. I. Effect of hyperosmolar mannitol infused through the internal carotid artery"],"prefix":"10.1002","volume":"185","author":[{"given":"Zoltan","family":"Nagy","sequence":"first","affiliation":[]},{"given":"Hanna M.","family":"Pappius","sequence":"additional","affiliation":[]},{"given":"Gordon","family":"Mathieson","sequence":"additional","affiliation":[]},{"given":"Istvan","family":"H\u00fcttner","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901520402"},{"key":"e_1_2_1_3_1","first-page":"468","volume-title":"Capillary Permeability","author":"Brightman M. 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