{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:16:36Z","timestamp":1778933796094,"version":"3.51.4"},"reference-count":71,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":8974,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1980,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The projections of the nucleus of the solitary tract (NST) were studied by autoradiographic anterograde fiber\u2010tracing and horseradish peroxidase (HRP) retrograde cell\u2010labeling. Tritiated proline and leucine were deposited in electrophysiologically identified regions of NST. Injections of NST at levels caudal to where the vagus enters the nucleus, from which responses were evoked by stimulation of cranial nerves IX and X, revealed topographically organized bilateral projections to, most prominently, the ventrolateral medullary reticular formation which contains neurons of the ambiguus complex, and to the lateral and medial parabrachial nuclei, including a small portion of the medially adjacent central gray substance. Labeled fibers in the ventrolateral reticular formation were present from the nucleus retroambigualis rostralward to the retrofacial nucleus, with the densest concentration located over the nucleus ambiguus proper. The parabrachial projection was confirmed using HRP and shown to originiate from cells in the medial subdivision of NST. Due to the problem of fibers en passant, it was not possible to interpret conclusively the cell\u2010labeling seen around the solitary tract after HRP injections made in the region of the nucleus ambiguus. Labeled fibers were also traced from caudal NST to the dorsal motor nucleus of the vagus, but their origin could not be determined with certainty. Other labeled axons, traced to circumscribed parts of the inferior olivary complex and via the contralateral medial lemniscus to VPL of the thalamus, were shown in HRP experiments to originate from the dorsal column nuclei rather than NST. No labeled fibers were traced into the spinal cord, nor were any cells labeled in NST after large HRP deposits in upper cervical segments.<\/jats:p><jats:p>Isotope deposits at levels of NST rostral to the entrance of the vagus, from which responses were evoked by rapid stimulation of the tongue, revealed an ipsilateral projection which ascends as a component of the central tegmental tract to the parvicellular part of the ventral posteromedial thalamic nucleus (VPMpc). After small HRP deposits in VPMpc, labeled cells in NST were restricted to the rostral part of the lateral subdivision. No labeled axons were traced from rostral NST to the ambiguus complex or parabrachial area. Injections of <jats:sup>3<\/jats:sup>H\u2010amino acids at intermediate levels of NST resulted in fiber\u2010labeling in VPMpc, the parabrachial area, and the ambiguus complex.<\/jats:p>","DOI":"10.1002\/cne.901900205","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T23:13:42Z","timestamp":1104621222000},"page":"259-282","source":"Crossref","is-referenced-by-count":379,"title":["The nucleus of the solitary tract in the monkey: Projections to the thalamus and brain stem nuclei"],"prefix":"10.1002","volume":"190","author":[{"given":"Robert M.","family":"Beckstead","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel R.","family":"Morse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"Norgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900350403"},{"key":"e_1_2_1_3_1","first-page":"265","article-title":"Courants d'action bulbaires \u00e1 rhythme respiratoire","volume":"12","author":"Archard O.","year":"1954","journal-title":"Helv. Physiol. Acta"},{"key":"e_1_2_1_4_1","first-page":"410","article-title":"Localization of bulbar respiratory center by microelectrode sounding","volume":"35","author":"Bastel H. L.","year":"1964","journal-title":"Exp. Neurol."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00362221"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901840303"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4831-9834-7.50028-7"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901630304"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90406-7"},{"key":"e_1_2_1_10_1","first-page":"5","article-title":"Localisation et \u00e9tude des neurones respiratoires bulbaires","volume":"63","author":"Bianchi A. L.","year":"1971","journal-title":"J. Physiol. (Paris)"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901240110"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901180106"},{"key":"e_1_2_1_13_1","first-page":"175","article-title":"Localization of taste in the thalamus of Macaca mulatta Yale","volume":"16","author":"Blum M.","year":"1943","journal-title":"J. Biol., Med."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901610206"},{"key":"e_1_2_1_15_1","first-page":"306","article-title":"The origin of the ascending fibers of the medial longitudinal fasciculus from the vestibular nuclei: An experimental study in the cat","volume":"1","author":"Brodal A.","year":"1957","journal-title":"Acta Morphol. Neerlando Scand."},{"key":"e_1_2_1_16_1","volume-title":"The Vestibular Nuclei and Their Connections, Anatomy, and Functional Correlations","author":"Brodal A.","year":"1962"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901730408"},{"key":"e_1_2_1_18_1","volume-title":"Histologie du Systeme Nerveux de l'Homme et des Vertebres","author":"Cajal, S. Ram\u00f3n Y.","year":"1909"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901170110"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901780102"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901220304"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901610202"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(72)90344-7"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091480106"},{"key":"e_1_2_1_25_1","first-page":"126","article-title":"Localization of modality\u2010specific thalamic units that respond to stimulation of the cat tongue","volume":"35","author":"Emmers R.","year":"1964","journal-title":"Neurophysiologist"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-121-30821"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901180104"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90512-X"},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/00005053-192703000-00004","article-title":"The columnar arrangement of the primary afferent centers in the brain stem of man","volume":"65","author":"Freeman W.","year":"1927","journal-title":"J. Nerv. Ment. Dis."},{"key":"e_1_2_1_30_1","first-page":"50","volume-title":"The Physiological and Behavioral Aspects of Taste","author":"Frommer G. P.","year":"1961"},{"key":"e_1_2_1_31_1","first-page":"91","article-title":"Les voies centrales de al sensibilit\u00e9 et du gout et leurs terminaisons thalamiques","volume":"35","author":"Gerebtzoff M. A.","year":"1939","journal-title":"Cellule"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/13813454109148754"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901620407"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1965.209.1.105"},{"key":"e_1_2_1_35_1","first-page":"371","article-title":"\u00dcber eine bulbo\u2010spinale Bahn","volume":"10","author":"Hirose K.","year":"1961","journal-title":"Folia Neuro\u2010Biol. (Leipzig)"},{"key":"e_1_2_1_36_1","first-page":"295","article-title":"The secondary visceral\u2010gustatory tract in the cat","volume":"35","author":"Johnson F. H.","year":"1964","journal-title":"Anat. Rec."},{"key":"e_1_2_1_37_1","first-page":"2405","article-title":"Neuroanatomical organization of the respiratory centers","volume":"36","author":"Kalia M.","year":"1977","journal-title":"Fed. Proc."},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90243-3"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1962.00450220006003"},{"key":"e_1_2_1_40_1","first-page":"447","article-title":"Central gustatory pathways in the monkey: An experimental study","volume":"35","author":"Kinney F. C.","year":"1976","journal-title":"Anat. Rec."},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(78)90172-3"},{"key":"e_1_2_1_42_1","first-page":"29","article-title":"Experimentelle Untersuchungen \u00fcber den Ursprung des N Vagus and die centralen Edigungen der dem Plexus Nodosus entstammenden sensiblen Vagusfasern, sowie \u00fcber den Verlauf ihrer secund\u00e4ren Bahn","volume":"4","author":"Kosaka K.","year":"1905","journal-title":"Neurologia (Shinkeiguku Zashi, Tokyo)"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(68)90052-8"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.176.4042.1416"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90016-4"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901810211"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4831-9834-7.50034-2"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90519-3"},{"key":"e_1_2_1_49_1","first-page":"451","volume-title":"Essays on the Nervous System","author":"Merrill E. G.","year":"1974"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/26.2.24068"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)90760-4"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901300402"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(61)90027-9"},{"key":"e_1_2_1_54_1","first-page":"472","article-title":"The pars intermedia or nervus intermedius of Wrisberg, and the bulbo\u2010pontine gustatory nucleus in man","volume":"4","author":"Nageotte J.","year":"1906","journal-title":"Rev. Neurol. Psychiat."},{"key":"e_1_2_1_55_1","series-title":"Henry Ford Hosp. Int. Symp.","first-page":"3","volume-title":"Reticular Formation of the Brain","author":"Nauta W. J. H.","year":"1958"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)90942-1"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901660103"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(78)90102-1"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.173.4002.1136"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901500208"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900340305"},{"key":"e_1_2_1_62_1","first-page":"196","volume-title":"Comparative Neurology","author":"Papez J. W.","year":"1929"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1944.7.3.171"},{"key":"e_1_2_1_64_1","first-page":"455","volume-title":"Sensory Communication","author":"Pfaffmann C.","year":"1961"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1966.00470110074010"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1992.tb02935.x"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90089-0"},{"key":"e_1_2_1_68_1","first-page":"541","article-title":"Regrograde transport of dopamine\u2010\u03b2\u2010hydrozylase antibody (AD\u03b2H) by CNS noradrenergic neurons: Hypothalmic noradrenergic innervations","volume":"35","author":"Silver M. A.","year":"1978","journal-title":"Anat. Rec."},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/62.1.41"},{"key":"e_1_2_1_70_1","first-page":"314","article-title":"The spinal projection from the nucleus of the solitary tract An experimental study in the cat","volume":"90","author":"Torvik A.","year":"1957","journal-title":"J. Anat. (Lond.)"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900710105"},{"key":"e_1_2_1_72_1","first-page":"424","article-title":"Activation of solitary nucleus neurons from the locus coeruleus and vicinity","volume":"1","author":"Ward D. G.","year":"1975","journal-title":"Neurosci. Abstr."}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.901900205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.901900205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T22:57:58Z","timestamp":1699829878000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.901900205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,3,15]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1980,3,15]]}},"alternative-id":["10.1002\/cne.901900205"],"URL":"https:\/\/doi.org\/10.1002\/cne.901900205","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,3,15]]}}}