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By backfilling retinal ganglion cells from one optic tract with horseradish peroxidase we examined the origins of the retinofugal projections. Filled cells ipsilateral to the injected tract were concentrated in a crescent\u2010shaped area bordering the inferior temporal retina. In black mice this area constituted 20% of the total retinal area, in albinos 17%. In black mice we counted nearly 1,000 labeled cell in the ipsilateral retina, or 2.6% of all cells filled in both eyes. Albinos had about one\u2010third fewer filled cells ipsilaterally than black mice. Four percent of all ipsilaterally filled cells in black mice and 8% in albinnos were scattered outside of the crescent region. The density of ipsilaterally projecting cells was uniform throughout the crescent region in black mice, but decreased toward the central retina in albinos.<\/jats:p><jats:p>In retinas contralateral to the injection up to 39,000 cells were filled\u2014about two\u2010thirds of the cells in the ganglion\u2010cell layer whose cytoplasm contained conspicuous Nissl substance. Depending on classification of unfilled cells as ganglion cells or interneurons, we estimated a total 48,000 to 65,000 ganglion cells to exist in the retina.<\/jats:p><jats:p>The size distribution of ipsilateraly projecting ganglion cells was similar in albinos and normals. Ipsilaterally projecting ganglion cells were on average 1.8\u20133 times larger in volume than contralaterally projecting ones in both types of mice.<\/jats:p><jats:p>Displaced ganglion cells were relatively more common in ipsilateral retinofugal projections: 21% of all ipsilateral ganglion cells were displaced versus less than 1% of all the contralateral ganglion cells in black mice. In albinos only 13% of the ganglion cells in the ipsilateral retina were displaced. The overall reduction in ipsilaterally projecting cells in albinos was reflected twice as much in displaced ganglion cells as in normally placed ones.<\/jats:p>","DOI":"10.1002\/cne.901910306","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T23:16:16Z","timestamp":1104621376000},"page":"383-412","source":"Crossref","is-referenced-by-count":285,"title":["Origins of crossed and uncrossed retinal projections in pigmented and albino mice"],"prefix":"10.1002","volume":"191","author":[{"given":"Ursula C.","family":"Dr\u00e4ger","sequence":"first","affiliation":[]},{"given":"John F.","family":"Olsen","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(77)90074-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901370102"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1969.0004"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1974.sp010616"},{"key":"e_1_2_1_6_1","first-page":"73","article-title":"Direct accessory optic projections to the vestibulo\u2010cerebellum: a possible channel for oculomotor control systems","volume":"28","author":"Brauth S. 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