{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:49:15Z","timestamp":1778885355791,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":7740,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1983,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The neuronal distribution of 7\u2010aminobutyric acid (GABA) transaminase (GABA\u2010T), the enzyne which metabolizes GABA, has been mapped in rat brain. The method involves staining for newly synthesized GABA\u2010T by the previously established nitro blue tetrazolium technique in animals killed 8\u201348 hours after administration of gabaculine, an irreversible inhibitor of GABA\u2010T. Neuronal staining is obscured by staining of other elements if initial suppression is inadequate or survival times postgabaculine are too long. With appropriate conditions, GABA\u2010T\u2010positive neuronal somata can be widely detected. The stained cells include neuronal groups previously reported to be GAB Aergic on the basis of glutamate decarboxylase (GAD)\u2010col\u2010chicine immunocytochemistry and other methods, i.e.: Purkinje, basket, Golgi, and stellate neurons of the cerebellum; basket and stellate neurons of the hippocampus; granule and periglomerular cells of the olfactory bulb; magnocellular neurons of the hypothalamus; and neurons of the striatum, pallidum, entopeduncular nucleus, cortex, medial septal area, diagonal band, substantia innominata, reticular nucleus of the thalamus, substantia nigra, and dorsal raphe. Other cells that stain intensely for GABA\u2010T and may be GABAergic include neurons in the midlateral septal area, accumbens, the central medial and basal. nucler of the amyugdala, zona in certa, the brainstem reticular formation, central gray, interstitial nucleus of Cajal, and various thalamic nuclei including the periventricular, intralami\u2010nar, rhomboid, and subparafascicular. Known non\u2010GABA neuronal groups are negative for GABA\u2010T staining under these conditions, reinforcing the hypothesis that GABA neurons are far more GABA\u2010T intensive than other neurons.<\/jats:p>","DOI":"10.1002\/cne.902180209","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T18:59:47Z","timestamp":1104605987000},"page":"220-238","source":"Crossref","is-referenced-by-count":190,"title":["Distribution of GABA\u2010T\u2010Intensive neurons in the hat forebrain and midbrain"],"prefix":"10.1002","volume":"218","author":[{"given":"T.","family":"Nagai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. L.","family":"McGeer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. G.","family":"McGeer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"113","volume-title":"GABA in Nervous System Function","author":"Barber R.","year":"1976"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90107-0"},{"key":"e_1_2_1_4_1","first-page":"137","volume-title":"Handbook of the Hypothalamus","author":"Bleier R.","year":"1979"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01663629"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1073\/pnas.76.4.2067","article-title":"Immunocytochemical localization of \u03b3\u2010aminobutyric acid transaminase at cellular and ultrastruc\u2010tural levels","volume":"4","author":"Chan\u2010Palay V.","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"160","key":"e_1_2_1_7_1","first-page":"7","article-title":"Immunohistochemical localization of glutamate decar box\u2010ylase and met\u2010enkephalin\u2010like immunoreactivity in the septal complex of the rat","volume":"8","author":"Cheney D. L.","year":"1982","journal-title":"Neurosci. Abstr."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(80)90022-6"},{"key":"e_1_2_1_9_1","first-page":"109","article-title":"Active\u2010site\u2010directed irreversible inhibition of rat brain 4\u2010aminobutyrate amino transferase by ethanolamine\u2010O\u2010sulfate in vitro and in vivo","volume":"82","author":"Fowler L. J.","year":"1972","journal-title":"Biochem. J."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(79)91527-1"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90116-0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90925-7"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)90896-8"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02462790"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00490126"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/cne.901540402","article-title":"Retrograde axonal transport and the demonstration of non\u2010specific projections to the cerebral cortex and striatum from thalamic intralaminar nuclei in the rat, cat and monkey","volume":"154","author":"Jones E. G.","year":"1977","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1126\/science.6990490","article-title":"Choline acetyltransferase containing neurons in rodent brain by immunohisto\u2010chemistry","volume":"208","author":"Kimura H.","year":"1980","journal-title":"Science"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902000202"},{"key":"e_1_2_1_19_1","volume-title":"The Rat Brain. Huntington","author":"Konig J. F. R.","year":"1963"},{"key":"e_1_2_1_20_1","volume-title":"Compartmentation and Neurotransmitter Interaction","author":"McGeer E. G.","year":"1981"},{"key":"e_1_2_1_21_1","volume-title":"Molecular Neurobiology of the Mammalian Brain","author":"Eccles P. L. J. C.","year":"1978"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90768-0"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)90815-4"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90281-5"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(81)90115-9"},{"issue":"40","key":"e_1_2_1_26_1","first-page":"8","article-title":"The Gabaergic pallido\u2010nigral complex in the rat demonstrated by glutamic acid decarboxylase immunocytochemistry","volume":"8","author":"Oertel W. H.","year":"1982","journal-title":"Neurosci. Abstr."},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(77)90993-7"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01173991"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90211-6"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90463-8"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901870203"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90893-8"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01002711"},{"issue":"43","key":"e_1_2_1_34_1","first-page":"7","article-title":"Multiple neurotransmitter studies in the islands of Calleja complex of the basal forebrain","volume":"6","author":"Richman L.","year":"1980","journal-title":"Neurosci. Abstr."},{"key":"e_1_2_1_35_1","first-page":"365","article-title":"Distribution and localization of sites of gamma aminobutyric acid metabolism in the adult rat brain","volume":"114","author":"Robinson N.","year":"1973","journal-title":"J. Anat."},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.2.269"},{"issue":"188","key":"e_1_2_1_37_1","first-page":"8","article-title":"Quantitative histochemical measurement of GABA\u2010transamin\u2010ase: Method for evaluation of intracerebral lesions produced by excito\u2010toxic agents","volume":"8","author":"Sarvey C.","year":"1982","journal-title":"Neurosci. Abstr."},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410020407"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901920408"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1965.tb06759.x"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(80)90023-3"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(80)90309-4"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90959-8"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)91277-X"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)91239-2"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1159\/000123288"},{"key":"e_1_2_1_47_1","first-page":"133","volume-title":"GABA in Nervous System Function","author":"Wood J. G.","year":"1976"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902180209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902180209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T12:19:42Z","timestamp":1697804382000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902180209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,8]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,8]]}},"alternative-id":["10.1002\/cne.902180209"],"URL":"https:\/\/doi.org\/10.1002\/cne.902180209","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,8]]}}}