{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:38:48Z","timestamp":1771627128671,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":7155,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1985,3,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We used light and electron microscopic immunocytochemical methods to examine the structure of neuronal perikarya and processes containing cholecystokinin\u2010like immunoreactivity (CCK\u2010IR) in area CA1 of the rat hippocampus. The morphology of stained perikarya, their positions within all laminae, and the orientation of their dendrites indicate that CCK\u2010IR is located in interneurons. These cells were seen in the electron microscope to have deeply folded nuclei and to receive both symmetric and asymmetric synaptic junctions on their cell somata and dendritic shafts. Their dendrites are essentially spine\u2010free, but form bulges at the site of some asymmetric synaptic junctions. Axonal varicosities containing CCK\u2010IR make symmetric synaptic junctions with cell somata and dendritic shafts of both pyramidal and non\u2010pyramidal neurons. In addition, CCK\u2010IR varicosities form symmetric junctions with unstained non\u2010pyramidal neurons and with CCK\u2010IR cells, suggesting either recurrent innervation of one cell on itself or interaction between interneurons. The presence of CCK\u2010IR varicosities and synaptic junctions on pyramidal cells is in agreement with physiological data which indicate that CCK has a direct postsynaptic action. The observation of CCK\u2010IR varicosities forming synaptic junctions on non\u2010pyramidal cells suggests that CCK might also modify the response of interneurons.<\/jats:p>","DOI":"10.1002\/cne.902330202","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T19:27:10Z","timestamp":1104607630000},"page":"147-158","source":"Crossref","is-referenced-by-count":64,"title":["Ultrastructural study of cholecystokinin\u2010immunoreactive cells and processes in area CA1 of the rat hippocampus"],"prefix":"10.1002","volume":"233","author":[{"given":"Kristen M.","family":"Harris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia E.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis M. D.","family":"Landis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014255"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1980.sp013363"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1964.27.4.608"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1964.27.4.592"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1984.sp015065"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a071769"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/273674a0"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90344-9"},{"key":"e_1_2_1_10_1","first-page":"125p","article-title":"Excitation of CA1 neurones of the rat hippocampus by the octacosapeptide, vasoactive intestinal polypeptide","volume":"66","author":"Dodd J.","year":"1979","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_1_11_1","first-page":"63","article-title":"Cholecystokinin and vasoactive intestinal polypeptide in the mammalian CNS: Distribution and possible physiological roles","volume":"22","author":"Emson P. C.","year":"1980","journal-title":"Adv. Biochem. Psychopharmacol."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(80)90603-7"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90344-X"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)91328-1"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901980211"},{"key":"e_1_2_1_16_1","first-page":"247","article-title":"Hippocampal formation. IV. Interneurons","volume":"3","author":"Gayoso M. J.","year":"1979","journal-title":"Morfol. Normal Patol."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902030303"},{"key":"e_1_2_1_18_1","first-page":"858","article-title":"Hippocampal cholecystokinin\u2010like neurons\u2014a fluorescence retrograde labeling study","volume":"9","author":"Greenwood R. S.","year":"1983","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)91130-6"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.8.2400"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(80)90127-X"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/29.4.6166661","article-title":"The use of avidin\u2010biotin\u2010peroxidase (ABC) in immunoperoxidase techniques. A comparison between ABC and unlabeled antibody (PAP) procedures","volume":"29","author":"Hsu S\u2010M.","year":"1981","journal-title":"J. Histochem. Cytochem."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014228"},{"key":"e_1_2_1_24_1","first-page":"133","article-title":"Cholecystokinin and gastrin as transmitters in the mammalian central nervous system","volume":"28","author":"Kelly J. S.","year":"1981","journal-title":"Adv. Biochem. Psychopharmacol."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902100204"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014805"},{"key":"e_1_2_1_27_1","first-page":"67.2","article-title":"Immunohistochemistry of somatostatin in CA1 of rabbit hippocampus","volume":"9","author":"Kunkel D. D.","year":"1983","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90802-1"},{"key":"e_1_2_1_29_1","first-page":"113","article-title":"Studies on the structure of the cerebral cortex. II. Continuation of the study of the ammonic system","volume":"46","author":"Lorente De N\u00f3 R.","year":"1934","journal-title":"J. Psychol. Neurol."},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0006-8993(82)90262-1","article-title":"Origin and distribution of cholecystokinin\u2010containing nerve terminals in the lumbar dorsal horn end nucleus caudalis of the cat","volume":"243","author":"Maderut J. L.","year":"1982","journal-title":"Brain Res."},{"key":"e_1_2_1_31_1","first-page":"67.1","article-title":"Light and electron microscopic studies of rat hippocampal cells containing cholecystokinin immunoreactivity in area CA1","volume":"9","author":"Marshall P. E.","year":"1983","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(82)90261-2"},{"key":"e_1_2_1_33_1","first-page":"67.3","article-title":"Electrophysiological actions of somatostatin (SRIF) in rabbit hippocampus studied in vitro. Soc","volume":"9","author":"Mueller A. L.","year":"1983","journal-title":"Neurosci. Abstr."},{"key":"e_1_2_1_34_1","first-page":"85.10","article-title":"CCK neurons of the hippocampus and subiculum: Possible extra\u2010hippocampal projections","volume":"9","author":"Nelson J. B.","year":"1983","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/287022a0"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(83)90190-2"},{"key":"e_1_2_1_37_1","first-page":"615","article-title":"Beityrage zur feineren Anatomie des grossen Hirns, I. Uber die feinere Struktur des Ammonshornes","volume":"56","author":"Ramon y Cajal S.","year":"1893","journal-title":"Z. Wisse. Zool."},{"key":"e_1_2_1_38_1","volume-title":"The Structure of Ammon's Horn","author":"Ramon y Cajal S.","year":"1893"},{"key":"e_1_2_1_39_1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0300-5089(21)00473-9","article-title":"Cholecystokinin","volume":"9","author":"Rehfeld J. F.","year":"1980","journal-title":"Clin. Gastroenterol."},{"key":"e_1_2_1_40_1","first-page":"2325","article-title":"Gastrin and cholecystokinin in central and peripheral neurons","volume":"38","author":"Rehfeld J. F.","year":"1979","journal-title":"Fed. Proc."},{"key":"e_1_2_1_41_1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/BF01002711","article-title":"Immunocytochemical localization of GABAergic neurons at the electromicroscopical level","volume":"13","author":"Ribak C. E.","year":"1981","journal-title":"Histochem. J."},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)91213-1"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(84)90214-8"},{"key":"e_1_2_1_44_1","first-page":"413","article-title":"The role of neuropeptides in the hippocampal formation","volume":"33","author":"Siggins G. R.","year":"1982","journal-title":"Adv. Biochem. Psychopharmacol."},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90263-2"},{"key":"e_1_2_1_46_1","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1523\/JNEUROSCI.03-07-01450.1983","article-title":"Glutamate decarboxylase immunoreactivity in the hippocampus of the cat: Distribution of immunoreactive synaptic terminals with special reference to the axon initial segment of pyramidal neurons","volume":"3","author":"Somogyi P.","year":"1983","journal-title":"J. Neurosci."},{"key":"e_1_2_1_47_1","doi-asserted-by":"crossref","unstructured":"Storm\u2010Mathisen J. andF.Fonnum(1972)Localization of transmitter candidates in the hippocampal region. In P.B. Bradley and R.W. Brimble (eds):","DOI":"10.1016\/S0079-6123(08)62507-8"},{"key":"e_1_2_1_47_2","first-page":"41","article-title":"Biochemical and Pharmacological Mechanisms Underlying Behavior","volume":"36","journal-title":"Prog. Brain Res."},{"key":"e_1_2_1_48_1","first-page":"297","article-title":"Interneurons: An electron microscopic study of the cat's hippocampal formation","volume":"27","author":"T\u00f6mb\u00f6l T.","year":"1979","journal-title":"Acta Morphol. Acad. Sci. Hung."},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.2.1190"},{"key":"e_1_2_1_50_1","first-page":"121.2","article-title":"Study of GABAergic non\u2010pyramidal neurons in plexiform layers and deep white matter of rat hippocampus","volume":"9","author":"Vickrey B. G.","year":"1983","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_51_1","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1152\/jn.1982.48.4.938","article-title":"Cellular factors influencing GABA response in hippocampal pyramidal cells","volume":"48","author":"Wong R. K. S.","year":"1982","journal-title":"J. Neurophysiol."}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902330202","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902330202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T13:34:16Z","timestamp":1697808856000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902330202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3,8]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1985,3,8]]}},"alternative-id":["10.1002\/cne.902330202"],"URL":"https:\/\/doi.org\/10.1002\/cne.902330202","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,3,8]]}}}