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A specific population of horizontal cells appears to be mature at birth and they avidly accumulate <jats:sup>3<\/jats:sup>H\u2010GABA during a 15\u2010minute incubation period <jats:italic>in vitro<\/jats:italic>. Uptake into horizontal cells is not observed after the fifth postnatal day; <jats:sup>3<\/jats:sup>H\u2010GABA\u2010accumulating horizontal cell bodies and their processes are the first identifiable components that clearly mark the future location of the outer plexiform layer at birth and as such, may be considered pioneering elements. Our observations raise the interesting possibility that the pioneering horizontal cell may provide structural and\/or chemical factors necessary for the subsequent development of the outer plexiform layer of the retina.<\/jats:p><jats:p>Labeling patterns of other retinal cells also show varying degrees of change during development. (1) A population of amacrine cells accumulate <jats:sup>3<\/jats:sup>H\u2010GABA at birth. These cells show little change in their morphological or <jats:sup>3<\/jats:sup>H\u2010GABA uptake properties from birth to adulthood. (2) M\u00fcller cells show weak accumulation of <jats:sup>3<\/jats:sup>H\u2010GABA at birth. Subsequent to this time, labeling of M\u00fcller cells is significantly more robust, resulting in M\u00fcller cell domination of retinal autoradiographic patterns in more mature retinas. (3) Every cell body in the ganglion cell layer accumulates <jats:sup>3<\/jats:sup>H\u2010GABA at birth. The number of labeled cells declines during postnatal development, resulting in a very limited adult population. We conclude that the ability of retinal cells to accumulate <jats:sup>3<\/jats:sup>H\u2010GABA does not remain constant during postnatal development; rather each cell population displays a unique maturation sequence that results in a dramatic developmental shift in the number and types of GABA\u2010accumulating cells present in the retina.<\/jats:p>","DOI":"10.1002\/cne.902430105","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T18:14:49Z","timestamp":1104603289000},"page":"41-57","source":"Crossref","is-referenced-by-count":60,"title":["Postnatal development of <sup>3<\/sup>H\u2010GABA\u2010 accumulating cells in rabbit retina"],"prefix":"10.1002","volume":"243","author":[{"given":"Dianna A.","family":"Redburn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Paul","family":"Madtes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901560107"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90779-9"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901880204"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901980209"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(77)90089-6"},{"key":"e_1_2_1_7_1","first-page":"457","article-title":"GABA or sodium bromide induced plasticity of neurites of mouse neuroblastoma cells in culture; a quantitative study","volume":"229","author":"Elins S.","year":"1983","journal-title":"Cell Tissue Res."},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1523\/JNEUROSCI.02-11-01623.1982","article-title":"Prenatal development of GABAergic glycinergic and dopaminergic neurons in the rabbit retina","volume":"2","author":"Fung S.","year":"1982","journal-title":"J. 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